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- CAS号：
89838-96-0
- 规格：
1mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mg | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2000.0 |
| 规格： | 10mg | 产品价格： | ￥2984.0 |
| 规格： | 25mg | 产品价格： | ￥4712.0 |
| 规格： | 50mg | 产品价格： | ￥6632.0 |
| 规格： | 100mg | 产品价格： | ￥8960.0 |
| 规格： | 500mg | 产品价格： | ￥17840.0 |
Product Introduction
Bioactivity
| 名称 | Octimibate |
| 描述 | Octimibate (Octimibato) is a non-prostaglandin platelet aggregation inhibitor and cyclic prostaglandin agonist.Octimibate is used in the treatment of cardiovascular disease and can be used to study atherosclerosis and thrombosis. |
| 体外活性 | In suspensions of washed (plasma-free) human platelets, octimibate is a potent inhibitor of aggregation; its IC50 is approx 10 nM for inhibition of aggregation is stimulated by several different agonists, including U46619 and ADP. The inhibitory effects of octimibate on aggregation are not competitive with the stimulatory agonist; the maximal response is suppressed but there is no obvious shift in potency of the agonist. In platelet-rich plasma, octimibate inhibits agonist-stimulated aggregation with an IC50 of approx 200 nM.[2] Octimibate increases cyclic AMP concentrations in platelets and increases the cyclic AMP-dependent protein kinase activity ratio. Octimibate stimulates adenylyl cyclase activity in human platelet membranes, with an EC50 of 200 nM. The maximal achievable activation of adenylyl cyclase by intimidate is 60% of that obtainable with iloprost. Octimibate has no effect on the cyclic GMP-inhibited phosphodiesterase (phosphodiesterase-ITI), which is the major cyclic AMP-degrading enzyme in human platelets.[2] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 50 mg/mL (110 mM), Sonication is recommended. |
| 关键字 | ProstaglandinReceptor | Prostaglandin Receptor | Octimibate |
| 相关产品 | Rutin | Evodiamine | Lornoxicam | p-Hydroxycinnamic acid | Nepafenac | Rebamipide | Ethamsylate | Tranilast | Ufenamate | Angoroside C | Ozagrel | Pranoprofen |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | Anti-Cardiovascular Disease Compound Library | GPCR Compound Library | Antioxidant Compound Library | Immunology/Inflammation Compound Library | Membrane Protein-targeted Compound Library | Pain-Related Compound Library | Human Metabolite Library |
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辛米贝特【89838-96-0】
￥800 - 17840
