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- CAS号：
147059-72-1
- 规格：
1mg/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥253.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥596.0 |
| 规格： | 10mg | 产品价格： | ￥984.0 |
| 规格： | 25mg | 产品价格： | ￥2288.0 |
| 规格： | 50mg | 产品价格： | ￥3648.0 |
| 规格： | 100mg | 产品价格： | ￥5112.0 |
| 规格： | 200mg | 产品价格： | ￥6896.0 |
Product Introduction
Bioactivity
| 名称 | Trovafloxacin |
| 描述 | Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive. |
| 体外活性 | In HepG2 cells, Trovafloxacin (20 μM; 24 hours; ) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH)[1]. Trovafloxacin (20 μM; 24 hours; HepG2 cells) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2[1]. Trovafloxacin is a potent TO-PRO-3 uptake inhibitor by apoptotic cells. Trovafloxacin also inhibits ATP release from apoptotic cells. Trovafloxacin is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[3]. |
| 体内活性 | In male C57BL/6 J mice, TNF-induced p65 nuclear translocation disrupted by Trovafloxacin (150 mg/kg; oral administration). Trovafloxacin treatment increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin increased serum levels of alanine amino transferases (ALT) and pro-inflammatory cytokines when administered in combination with lipopolysaccharide (LPS) or TNF to mice induces severe liver toxicity associated with vast apoptotic areas in the liver[1]. |
| 存储条件 | Store under nitrogen,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : Insoluble DMSO : 4.17 mg/mL (10.02 mM), Sonication is recommended. |
| 关键字 | Trovafloxacin | topoisomerase-IV | Topoisomerase | TNF | pro-inflammatory | pneumococci | PANX1 | Pannexin 1 channel (PANX1) | NF-κB | LPS | Inhibitor | inhibit | hepatotoxicity | gyrase | DNAgyrase | DNA gyrase | DNA | broad-spectrum | bacterial | Antibiotic |
| 相关产品 | Adipic dihydrazide | Levulinic acid | Doxycycline | Neomycin sulfate | Terbinafine hydrochloride | BES | Dimethyl sulfoxide | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | D(+)-Raffinose pentahydrate |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | Drug-induced Liver Injury (DILI) Compound Library | Anti-Bacterial Compound Library | Anti-Infection Compound Library | Fluorochemical Library | FDA-Approved & Pharmacopeia Drug Library | FDA-Approved Drug Library | DNA Damage & Repair Compound Library | Orally Active Compound Library | Drug Repurposing Compound Library | Human Metabolite Library |
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