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- CAS号：
427-51-0
- 规格：
1mLx10mM(inDMSO)/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥292.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥153.0 |
| 规格： | 100mg | 产品价格： | ￥264.0 |
| 规格： | 200mg | 产品价格： | ￥386.0 |
Product Introduction
Bioactivity
| 名称 | Cyproterone acetate |
| 描述 | Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. |
| 体外活性 | 经Cyproterone acetate处理后,大鼠体内GST和超氧化物歧化酶活性显著降低,NO明显提高,MDA含量显著增加,反映了大鼠睾丸的氧化状态.Cyproterone acetate对生殖器官重量有直接的不良作用,且会使精子数量和 Ca2+含量显著降低.秋季人为的光照时长增加以及CA处理对精子运动及形态存在负面影响. 以Cyproterone acetate处理雄激素受体后,睾丸中精细胞鱼精蛋白水平会首先下降,核染色质浓缩过程涉及的精子水平也会下降. |
| 体内活性 | 在睾丸激素（10 nM）存在时,低浓度Cyproterone acetate对T-刺激的3XHRE-LUC转录具有抑制作用,高浓度作用则相反。Cyproterone acetate既有明显的拮抗性能亦有部分激活剂特性,相对浓度较高时可激活AR（EC50为4.0 μM）。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 10 mg/mL (23.98 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.8 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 35.71 mg/mL (85.65 mM), Sonication is recommended. |
| 关键字 | tumorigenesis | steroid | prostate | Inhibitor | inhibit | hormonal | DR5 | Cyproterone acetate | Cyproterone | cells | cancer | AndrogenReceptor | Androgen Receptor |
| 相关产品 | DHEA | Enzalutamide | Ostarine | S-23 | Flutamide | Sunset Yellow FCF | Allura Red AC | Dehydroisoandrosterone 3-acetate | Testosterone propionate | 2-Ethylhexyl trans-4-methoxycinnamate | 2-sec-Butylphenol | Octinoxate |
| 相关库 | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | FDA-Approved & Pharmacopeia Drug Library | NO PAINS Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Drug Library | NMPA-Approved Drug Library |
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文献和实验Functional Liposomal Membranes for Triggered Release
Treat 77:185–188, 2003; Lung Cancer 34:427–432, 2001; Cancer Chemother Pharmacol 50:131–136, 2002). It has been hypothesized that the enhanced release at the target site will significantly improve the specificity and efficacy of a liposomal drug (J
酶试验亦有相应的充化。从而阐明了他们之间的内在联系和变化规律，为溃疡病的辨证分型提出了新的依据，寻找有效药方开辟了新的思维途径。 1 对象和方法 1．1 对象 男427例，女73例，年龄最小18岁，最大73岁，其中18岁～30岁151例，31岁～40岁136例，41～50岁129例，51～60岁63例，60岁以上21例，平均38.6岁。病史最长28a ，最短4d，平均3.7a。全部病例均经纤维胃镜确诊为十二指肠溃疡。 1．2 方法 ①胃镜
日本安力ANEX 塑胶手柄螺丝刀 NO.1110 0*100
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