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- 文献和实验
- 技术资料
- CAS号:
879399-82-3
- 规格:
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg
| 规格: | 1mLx10mM(inDMSO) | 产品价格: | ¥1336.0 |
|---|---|---|---|
| 规格: | 1mg | 产品价格: | ¥518.0 |
| 规格: | 5mg | 产品价格: | ¥1184.0 |
| 规格: | 10mg | 产品价格: | ¥1808.0 |
| 规格: | 25mg | 产品价格: | ¥2832.0 |
| 规格: | 50mg | 产品价格: | ¥3816.0 |
| 规格: | 100mg | 产品价格: | ¥5232.0 |
Product Introduction
Bioactivity
| 名称 | CCR3 antagonist 1 |
| 描述 | CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases. |
| 存储条件 | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : 10 mg/mL (20.39 mM), Suspension. DMSO : 125 mg/mL (254.88 mM), Sonication is recommended. |
| 关键字 | CCR-3 antagonist 1 | CCR3 antagonist 1 | CCR3 |
| 相关产品 | BMS-817399 | Maraviroc | Pirfenidone | Ancriviroc | AZD2098 | Vercirnon | PNU-177864 | CCR2 antagonist 5 | Artemotil | MLN-3897 TFA | INCB-9471 | CCR6 antagonist 1 |
| 相关库 | Immuno-Oncology Compound Library | Chemokine Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Cytokine Inhibitor Library | ReFRAME Related Library | GPCR Compound Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library |
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文献和实验3和CCR3/4,因而可吸引不同的趋化因子,前者包括干扰素诱导蛋白(1P-10)、干扰素诱导性T细胞趋化蛋白(1TAC),干扰素诱生单核因子(MIG);而后者包括嗜酸粒细胞趋化蛋白Eotaxin等。现知细胞因子IL-4促进Th2分化,第十章中还将提到IL-4能促进IgE类别转换,而且IL-4(以及IL-13)还可诱导多种细胞包括单核细胞和DC产生趋化因子。结果是,这些趋化因子受体可专一性地吸引表达CCR3和CCR4的Th2/Tc2细胞,以及表达CCR3和IgE受体的嗜碱粒细胞与肥大细胞。这样,细胞
Quantitation of HIV-1 Entry Cofactor Expression
as the entry cofactor for T-cell line-tropic isolates of HIV-1 (4 ). Subsequent progress in the field has been rapid. To date, three β-chemokine receptors (CCR2b, CCR3, and CCR5) have also been identified as HIV-1 entry cofactors (5 ).
Quantitative Evaluation of HIV and SIV Co-Receptor Use With GHOST Cell Assay
4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, CXCR6/STRL33/Bonzo, or the orphan receptor GPR15/BOB. The indicator cell line carries the HIV-2 long terminal repeat-driven green fluorescence protein (GFP) gene, which becomes activated upon infection with HIV or SIV
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