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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one xhydrate
- 供应商：
上海安毕达生物科技有限公司
- CAS号：
849061-97-8
- 规格：
5g
Quercetin hydrate, known for its potent bioactivities as a natural flavonoid, functions as a significant enhancer of recombinant SIRT1 and as a PI3K inhibitor, displaying IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM for PI3K γ, δ, and β isoforms, respectively1.
Quercetin hydrate's application extends beyond supplements, beverages, or foods, owing to its anti-inflammatory and antioxidant properties. These properties make quercetin hydrate an attractive subject for research into its potential health benefits. Specifically, it robustly targets PI3K and Src kinases, moderately affects Akt1/2, and has a lesser impact on PKC, p38, and ERK1/21.
Quercetin hydrate's ability to inhibit TNF-induced LDH release, reduce EC-dependent neutrophil adhesion to BPAECs, and diminish BPAEC DNA synthesis and proliferation underscores its therapeutic potential2.
Additionally, when combined with 2-Methoxyestradiol at a dosage of 75 mg/kg, it significantly curtails tumor growth in xenograft models of human prostate cancer LNCaP and PC-3 cells, highlighting its potential in cancer therapy3.
Additionally, when combined with 2-Methoxyestradiol at a dosage of 75 mg/kg, it significantly curtails tumor growth in xenograft models of human prostate cancer LNCaP and PC-3 cells, highlighting its potential in cancer therapy3.
溶解方案(细胞实验)
DMSO 中的溶解度 : 30 mg/mL (超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)
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文献和实验Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.
Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277.
缺血再灌注损伤（ischemia/reperfusion Injury，IRI）中，细胞衰老的作用具有双重调节功能，调节衰老细胞可能是改善供体肾脏结果的潜在治疗靶点。人脐带间充质干细胞衍生的外泌体（HUMSC-EVs）在免疫调节和组织微环境稳态中起重要作用，能够通过减少氧化损伤、炎症细胞因子表达、抑制细胞凋亡等机制改善肾脏 IRI 的预后。本文旨在研究 HUMSC-EVs 通过抑制肾小管上皮细胞衰老来实现保护肾脏 IRI 的机制，并探讨了 HUMSC-EVs 与达沙替尼（dasatinib）和槲皮素（quercetin）联合
Flavonoids From Argentine Tagetes (Asteraceae) With Antimicrobial Activity
( 1 ). They are prominent components of citrus fruits and other food sources. Flavonols (quercetin, myricetin, and kaempferol) and flavones (apigenin and luteolin) are the most common phenolics in plant-based foods. Quercetin is also a predominant component of onions
buffer at pH 7, and subsequently measuring the developed absorbance at 450 nm after 30 min. Since the color development is fast for compounds like ascorbic acid, gallic acid, and quercetin but slow for naringin and naringenin, the latter compounds
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