Recombinant human TIGIT Fc-Fus

Product Type: Protein Alternative Name(s): T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3 Accession ID: Q495A1 Antigen: TIGIT Host: HEK293 Fc domain: human IgG1 Species: human Extinction Coefficient: 106090 Molecular Weight: 80340.82 Da Amino Acid Sequence: MMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPGGGGSEPKSQDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGHHHHHH Purity: >95% (SDS-PAGE) Buffer: PBS + 0.02% Proclin 300 Amount: 0.1mg Activity: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells [Uniprot]. Mycoplasma Tested: <1.0 EU/mg Storage: Store at 4C up to 1 month. Small volumes at -20C for longer storage. Shipped: Cold packs