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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名:
Mouse anti-Ezrin
- 规格:
0.1 mg
Purified Mouse anti-Ezrin (pT567) Clone J37-954.281.307 (RUO)
BD Pharmingen
Concentration
0.5 mg/ml
Isotype
Mouse BALB/c IgG1, κ
Reactivity
Human (QC Testing) Mouse, Rat (Predicted)
Application
Western blot (Routinely Tested)
Immunohistochemistry-formalin (antigen retrieval required) (Tested During Development)
Immunogen
Phosphorylated Ezrin Peptide
Storage Buffer
Aqueous buffered solution containing ≤0.09% sodium azide.
Description
Ezrin is a member of the ERM (Ezrin-Radixin-Moesin) family of proteins that can function as a crosslinker between the actin cytoskeleton and the plasma membrane of the cell. Phosphorylation of threonine residues (Thr567 on Ezrin, Thr564 on Radixin and Thr558 on Moesin) has been reported to occur with stimulation of growth factors and is important for cytoskeletal rearrangements. Phosphorylation of Thr567 at the C-terminal F actin-binding domain has been reported to activate the conversion of Ezrin from a dormant soluble form in the cytosol to a membrane- and actin-binding conformation.
In addition to its reactivity to the human species, the peptide used to generate this antibody is either identical or has homology to analogous regions of mouse and rat Ezrin, Radixin and Moesin. The J37-954.281.307 monoclonal antibody has been reported to recognize phosphorylated T567 on active Ezrin in addition to crossreacting on phosphorylated T564 on Radixin and phosphorylated T558 on Moesin.
| Cat No. | Description | Size | |
|---|---|---|---|
| 611447 | A431 Cell Lysate RUO | 500 µg |
|
| 554002 | HRP Goat Anti-Mouse Ig RUO | 1 mL |
|
| 610602 | Purified Mouse Anti-Ezrin 18/Ezrin RUO | 50 µg |
|
| 611448 | A431 + EGF Cell Lysate RUO | 500 µg |
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