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文献和实验TRAF‐Mediated TNFR‐Family Signaling
. Camerini, D., Walz, G., Loenen, W.A., Borst, J., and Seed, B. 1991. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J. Immunol. 147:3165
【信息】The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
signalling 1), which interacts with MAL causing it to be degraded. TRIF is used by TLR3, and leads to the activation of IRF3 through TBK1 (TRAF-family-member-associated NF-B activator-binding kinase 1). It is also involved in the NF-B activation pathway
PD-1是55KD的跨膜蛋白,与CD28、ICOS和细胞毒性T淋巴细胞(CTL)相关抗原4(CTLA-4)同属免疫球蛋白超家族成员。其胞外区只有1个IgV样区,与CTLA-4有23%的同源性,但无结合B7-1/B7-2必需的MYPPPY基序;胞浆区有2个酪氨酸残基,尾部有1个ITIM(immunoreceptor tryosine-based inhibitory motif),而无YXXM基序。其他CD28家族中的成员以二硫键连接的同源二聚体形式而存在,而PD-1则以单体形式存在。与CD
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