- ￥2640
- USA
- 1289-100ug
- USA
- 2025年08月17日
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- 详细信息
- 技术资料
- 保存条件：
低温
- 供应商：
研卉生物
- 英文名：
Selective protein kinase G inhibitor
- 库存：
1
- 规格：
100ug
KT 5823
Cat. No. 1289
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
Biological Activity
Selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.Technical Data
M.Wt: The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
References
Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626. PMID: 1528872.
Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171. PMID: 7840145.
Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 358 134. PMID: 9721015.
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