- ￥1373.13 - 5464.78
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- ALX-270-445
- 美国
- 2026年03月03日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
少量现货
- 英文名：
ALK5 Inhibitor II
- CAS号：
446859-33-2
- 保质期：
As indicated on product label or CoA when stored as recommended. Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C.
- 供应商：
欣博盛生物
- 保存条件：
-20°C
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥1373.13 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥5464.78 |
- Potent ATP-competitive inhibitor of the TGF-β type I receptor ALK5
- Useful for cellular reprogramming and the culture of human pluripotent stem cells
- Active in vitro and in vivo
- GMP format available
ALK5 inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation, and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). It minimally affects a panel of nine closely related kinases including p38 MAPKand GSK3 (IC50>16µM). It can be used for the induction of the pluripotency of stem cells by replacing the transcription factor SOX2 via the inhibition of TGF-β signaling and inducing the expression of the transcription factor Nanog.
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文献和实验- Controlling Human Stem Cell-Derived Islet Composition Using Magnetic Sorting: Kelley, A. B., Shunkarova, M., et al.; Biotechnol. Bioeng. 122, 2206 (2025), Abstract
- HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes: N.H.J. Ng, et al.; Nat. Commun. 15, 4288 (2024), Abstract
- Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling: Wang, C., Abadpour, S., et al.; Front. Bioeng. Biotechnol. 12, 1392575 (2024), Abstract
- Pump-Less, Recirculating Organ-on-Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver: Aizenshtadt, A., Wang, C., et al.; Adv. Healthc. Mater. 13, e2303785 (2024), Abstract
- Controlling human stem cell-derived islet composition using magnetic sorting: Kelley, A. B., Shunkarova, M., et al.; bioRxiv , (2024)
- Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells: Lim, S. W., Shin, Y. J., et al.; Kidney Res. Clin. Pract. 43, 236 (2024), Abstract
- Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation: Hogrebe, N. J., Schmidt, M. D., et al.; bioRxiv , (2024)
- Insulin regulates human pancreatic endocrine cell differentiation in vitro: P. Cota, et al.; Mol. Metab. 79, 101853 (2023), Abstract
- NEUROD2 function is dispensable for human pancreatic β cell specification: Cota, P., Saber, L., et al.; Front. Endocrinol. (Lausanne) 14, 1286590 (2023), Abstract
- Regulation of CTCF loop formation during pancreatic cell differentiation: Lyu, X., Rowley, M. J., et al.; Nat. Commun. 14, 6314 (2023), Abstract
Generation of Novel Rat and Human Pluripotent Stem Cells by Reprogramming and Chemical Approaches
) have been generated from both mouse and human somatic cells by genetic transduction. We had successfully established novel rat iPSCs (riPSCs), which can be homogenously maintained by LIF and a cocktail of ALK5 inhibitor, GSK3 inhibitor and MEK inhibitor. riPSCs share
266 8.1 Equilibrium Treatment of Reversible Inhibition / 268 8.2 Modes of Reversible Inhibition / 270 8.3 Graphic Determination of Inhibitor Type / 273 8.4 Dose—Response Curves of Enzyme Inhibition / 282 8.5 Mutually Exclusive Binding
17: 5' - cct gca act tga tgg aga tac c - 3' Expected RT- PCR product size: 211bp The primers are located on different exons that are separated by a 59bp intron. If genomic DNA is amplified, the product size would be 270bp. II. Use genomic DNA isolated
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