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文献和实验Overview of Approaches to the Identification of Inhibitors of Cytokine Action
in the first section. These concepts are illustrated using interleukin?2 (IL?2) as a prototype, since there is a substantial body of knowledge regarding this cytokine, including information on its functions, signaling pathways, and physiological effects in normal
Structure-Based Library Design in Efficient Discovery of Novel Inhibitors
Structure-based library design employs both structure-based drug design (SBDD) and combinatorial library design. Combinatorial library design concepts have evolved over the past decade, and this chapter covers several novel aspects
Structure-Based and Property-Compliant Library Design of 11-HSD1 Adamantyl Amide Inhibitors
tools and predictive models in the targeted library design of adamantyl amide 11β-HSD1 inhibitors is described. Specifically, the multiproperty profiling using our proprietary PGVL (Pfizer Global Virtual Library) Hub is discussed in conjunction
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