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- MCE
- HY-L011
- 2026年03月24日
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- 库存：
【化合物数量】1935
- 供应商：
广州市左克生物
大部分分子主要通过膜转运蛋白进出细胞，膜转运蛋白在细胞代谢、离子稳态、信号转导、免疫系统识别过程、能量转导等多种细胞功能中发挥重要作用。主要有三种转运蛋白，ATP 驱动的泵，通道蛋白和转运蛋白。离子通道和转运蛋白在维持细胞内稳态中发挥重要作用，这些转运蛋白基因的突变已在许多遗传疾病的发病机制中被发现。在中枢神经系统中，离子通道与许多疾病有关，如共济失调、麻痹、癫痫和耳聋等，但不限于此，这表明离子通道在启动和协调运动、感觉知觉以及信息编码和处理方面的作用。离子通道是药物开发中的一类主要靶点。 MCE 膜转运蛋白/离子通道库收录的 [0] 小分子调节剂可用于离子通道和膜转运体的研究，或相关药物的高通量筛选。
活性描述 & 特点
Biological Activity
• A unique collection of 2,042 small molecule modulators used for Ion Channel and Membrane Transporter research.
• The library contains compounds targeting Membrane Transporters including Pgp, CRM1, BCRP, etc., and Ion Channels including CFTR, proton pump, sodium pump, calcium pump, etc.
• A useful tool for the research of drug absorption and distribution.
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.
• Structurally diverse, medicinally active, and cell permeable.
• Rich documentation with structure, IC50, and summary.
• NMR and HPLC validated to ensure high purity.
• All compounds are in stock and continuously updated.
产品详情
Product Details
Formulation:
A collection of 2,042 Membrane Transporter/Ion Channel related compounds supplied as pre-dissolved Solutions or Solid
Solution: 2,005 compounds supplied in 10 mM solution, 35 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice or dry ice
化合物库组成
Composition
Potassium Channel(318)
Calcium Channel(289)
GABA Receptor(219)
iGluR(219)
Sodium Channel(207)
TRP Channel(184)
nAChR(130)
P-glycoprotein(80)
P2X Receptor(54)
Proton Pump(52)
CFTR(50)
Chloride Channel(49)
GLUT(30)
Na+/K+ ATPase(30)
SGLT(28)
EAAT(24)
Monoamine Transporter(22)
BCRP(21)
Na+/H+ Exchanger (NHE)(20)
ATP Synthase(19)
Calmodulin(17)
HCN Channel(16)
CRAC Channel(14)
Monocarboxylate Transporter(14)
URAT1(14)
Na+/Ca2+ Exchanger(13)
Aquaporin(12)
GlyT(12)
OAT(12)
ASCT(11)
NKCC(11)
Amino acid Transporter(9)
CRM1(7)
Ferroportin(6)
VDAC(6)
Apical Sodium-Dependent Bile Acid Transporter(5)
Piezo Channel(5)
ATP-binding cassette (ABC) transporters(4)
Nucleoside Transporters(4)
Synaptic Vesicle Proteins(3)
FATP(2)
Urea Transporter(2)
WNK Kinase(2)
Anion Exchangers(1)
Ferlin Family(1)
Na+/HCO3- Cotransporter(1)
Oligopeptide Cotransporter(1)
SLC39 (Zinc Transporter)(1)
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文献和实验Characterization of Calcium Channel Binding
calcium channels are expressed in a variety of tissues including heart, muscles and brain. Saturation binding of a radioligand to the calcium channel is commonly used to characterize the expression level of the channel protein. Compound competition binding
NMR Studies of Membrane Proteins
Nuclear magnetic resonance studies of membrane proteins yield valuable insights into their structure and topology. For example, the tilt angle and rotation of the helices in an ion channel can be determined by solid-state NMR spectroscopy
CFTR is the only member of the ABC (ATP-binding cassette) protein superfamily known to function as an ion channel. Most other ABC proteins are ATP-driven transporters, in which a cycle of ATP binding and hydrolysis, at intracellular
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