- ￥3840 - 7680
- Adipogen
- 瑞士
- AG-40B-0101-3010
- 2026年03月03日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
IL-38 (aa 3-152) (mouse) (rec.) (FLAG) MultiPack
- 保质期：
见包装说明
- 保存条件：
-20°C
- 库存：
99
- 供应商：
欣博盛生物
- 规格：
3 x 10 ug/10 ug
| 规格： | 3 x 10 ug | 产品价格： | ￥7680.0 |
|---|---|---|---|
| 规格： | 10 ug | 产品价格： | ￥3840.0 |
IL-38 (aa 3-152) (mouse) (rec.) (FLAG) MultiPack产品由Adipogen公司生产，产地是瑞士。该产品货号为AG-40B-0101-3010，包装规格是3 x 10 ug。如需购买该产品，询问折扣价/货期/技术问题，请联系Adipogen授权代理商——欣博盛生物
IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36α, IL-36β or IL-36γ) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.
Synonyms Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
Product Type Protein
Properties
Source/Host E. coli
Sequence
Mouse IL-38 [IL-1F10] (aa 3-152) is fused at the C-terminus to a FLAG®-tag.
Crossreactivity Mouse
MW ~20kDa
Purity ≥95% (SDS-PAGE)
Endotoxin Content <0.01EU/μg purified protein (LAL test; Lonza).
Concentration 0.1mg/ml after reconstitution.
Reconstitution Reconstitute with 100μl sterile water.
Formulation Lyophilized. Contains PBS + 0.5% Trehalose + 0.02% CHAPS.
Other Product Data
Uni-Prot link Q8R459: Interleukin-38
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
PBS containing at least 0.1% BSA should be used for further dilutions.
Use/Stability Stable for at least 6 months after receipt when stored at -20°C.
Working aliquots are stable for up to 3 months when stored at -20°C.
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文献和实验In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)/lpr mice: M. Chu, et al.; Immunobiology 222, 483 (2017)
The effect of interleukin 38 on angiogenesis in a model of oxygen-induced retinopathy: J. Zhang, et al.; Sci. Rep. 7, 2756 (2017)
The enigmatic role of IL-38 in inflammatory diseases: T. Garraud, et al.; Cytokine Growth Factor Rev. 39, 26 (2018)
Interleukin 38 protects against lethal sepsis: F. Xu, et al.; J. Infect. Dis. 218, 1175 (2018)
The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization: J. Zhu, et al.; Curr. Mol. Med. 19, 589 (2018)
Interleukin‐38 alleviates cardiac remodelling after myocardial infarction: Y. Wei, et al.; J. Cell. Mol. Med. 24, 371 (2020)
IL-38: A novel cytokine in systemic lupus erythematosus pathogenesis: W.D. Xu, et al.; J. Cell Mol. Med. 24,12379 (2020)
IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome: Y. Ge, et al.; Mediat. Inflamm. 6370911 (2021)
Therapeutic Effect of IL-38 on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Cell Pathogenicity: H. Li, et al.; Invest. Ophthalmol. Vis. Sci. 62, (2021)
Multifaceted roles of IL-38 in inflammation and cancer: A. Diaz-Barreiro, et al.; Cytokine 151, 155808 (2022)
IL-38, a potential therapeutic agent for lupus, inhibits lupus progression: WD. Xu, et al.; Inflamm. Res. 71, 963 (2022)
Regulatory effect of IL-38 on NF-κB pathway in systemic lupus erythematosus: J. Zhang, et al.; Immunobiol. 228, 152322 (2023)
purification of protein complexes, in combination with in vivo biotinylation of critical transcription factors, has contributed to the analysis of the pluripotent state in mouse embryonic stem (ES) cells and made it possible to construct a protein?protein
小弟是新手，刚开始做实验，向诸位请教一个问题。我要做一个蛋白的 IP,520个AA，58/55kDa，查文献都是用标签FLAG的抗体做的，但现在没有这个标签的真核表达载体，想直接转染后用目的蛋白的抗体做，不知 道可不可以？还有就是，什么时候用标签，什么时候可以不用？标签的选择有没有要求？请大家不吝指教，**！ps：小弟新虫，金币不多，大家见谅啊！问题：看的文献上都是用含标签的目的蛋白基因的载体转染细胞，然后做IP，我想，是不是目的蛋白的抗体不适合做IP，所以转染时需要加个标签，以便用标签
Intracellular Immunofluorescent Staining for Flow Cytometry
tested have stained appropriately using the Foxp3 buffers. Please contact Technical support for more information. Granzyme B & IL-17 Data Mouse/Human Granzyme B (GB
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