C253515-Cell-Del®ClodronateLip

氯磷酸盐二钠脂质体（Clodronate Liposomes）是一种成熟的巨噬细胞清除试剂，利用脂质体技术提高氯磷酸盐的靶向性和有效性。其作用机制是脂质体被巨噬细胞吞噬后，释放氯磷酸盐，干扰线粒体功能，导致巨噬细胞凋亡。它能有效清除动物体内肝脏、脾脏、肺部、血液等多个组织和部位的巨噬细胞，广泛应用于巨噬细胞清除的研究中。

Lipid composition: phosphatidylcholine, phosphotidyglycerol and cholesterol. Active: clodronate disodium. CAS: 22560-50-5. Clodronate disodium (liposome encapsulated): 5mg/mL.

Clodronate Liposome is a multilamellar liposome suspension in which clodronate is encapsulated in the aqueous compartments of the liposomes. When animals or cells are treated with Clodronate Liposome, phagocytic cells recognize the liposomes as invading foreign particles and proceed to remove the liposomes from the local tissue or serum via phagocytosis. The liposomes then release clodronate into the cytosol, resulting in cell death. Non-encapsulated clodronate cannot cross the cell membrane to initiate cell death.

Control Liposome are recognized and phagocytosed by the same mechanism as Clodronate Liposome, which do not contain clodronate, thus the phagocytic cells are not killed. However, phagocytes do respond to the ingestion of control liposomes by cytokine secretion, temporary suspension of phagocytic activity and other responses.