- ￥1900
- Biorigin
- BN40370R
- 2026年01月31日
- FCM,
- Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit,Sheep,
- 应用范围：
FCM,
- 抗体英文名：
AP2 alpha + beta
- 规格：
100ul
| 英文名称 | AP2 alpha + beta |
| 中文名称 | 转录因子AP2α+β抗体 |
| 别 名 | Activating enhancer binding protein 2 alpha; Activating enhancer binding protein 2 beta; AP2TF; TFAP2; TFAP2A; TFAP2B; Transcription factor AP2 alpha; Transcription factor AP2 beta; AP2A_HUMAN; AP2B_HUMAN. |
| 研究领域 | 肿瘤 发育生物学 转录调节因子 结合蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit, Sheep, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AP2 alpha + beta:201-300/437 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The AP2 proteins are normally expressed in ectodermally derived vertebrate tissues where they are necessary for normal growth and development. The factors have also been implicated in the control of cell proliferation, viral transformation, and oncogenesis. AP2 seems to play in important role in human breast cancer. AP2 alpha is the only AP2 protein required for early morphogenesis of the lens vesicle. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A-transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Subcellular Location: Nuclear. Post-translational modifications: Sumoylated on Lys-10; which inhibits transcriptional activity (Probable). DISEASE: Defects in TFAP2A are the cause of branchiooculofacial syndrome (BOFS) [MIM:113620]; also known as branchial clefts with characteristic facies, growth retardation, imperforate nasolacrimal duct, and premature aging or lip pseudocleft-hemangiomatous branchial cyst syndrome. BOFS is a rare autosomal dominant cleft palate craniofacial disorder with variable expressivity. The major features include cutaneous anomalies, ocular anomalies, characteristic facial appearance (malformed pinnae, oral clefts), and, less commonly, renal and ectodermal (dental and hair) anomalies. Similarity: Belongs to the AP-2 family. SWISS: P05549 Gene ID: 7020 Database links: Entrez Gene: 7020 Human Entrez Gene: 21418 Mouse Omim: 107580 Human SwissProt: P05549 Human SwissProt: P34056 Mouse Unigene: 519880 Human Unigene: 85544 Mouse Unigene: 22545 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验作为裂殖子逃逸并侵入新的RBC，或者成为雌性或多个雄性阶段，称为配子体。如果分裂体和裂殖子产生，宿主血液中受感染的细胞数量将会增加。然而，疟原虫只有在其生命周期中产生配子体才能传播到蚊子阶段。在蚊子中肠中，雄配子将使雌配子受精，由此产生的合子有可能穿过中肠壁进入寄生虫生命周期的下一阶段。转录因子AP2-G虽然触发这两种发育途径中的一种或另一种的分子机制还不清楚，但已知一种称为AP2-G的转录因子是启动在许多疟疾物种中产生配子的途径所必需的。这一发现在2014年的一篇博文中出现，并在一篇优秀的评论中详细
参与披网格蛋白小泡组装的一种蛋白质, 分子量为100kDa, 在披网格蛋白小泡组装中与受体的细胞质结构域相互作用, 起衔接作用。有两种类型衔接蛋白, AP1参与反面高尔基体的披网格蛋白小泡的组装, AP2则参与从细胞质膜形成的披网格蛋白的组装。 M6P受体蛋白既存在于反面高尔基体又存在于细胞质膜,所以这种受体既能同AP1作用又能与AP2相互作用。衔接蛋白AP2是一个二聚体,并且是由α衔接蛋白(α链)和β衔接蛋白(β链)两种衔接蛋白组成的异二聚体。 在酵母
Nat Metab：汤其群 / 郭亮团队发现半胱氨酸双加氧酶促进脂肪分解的新功能
促进脂肪组织 Cdo1 表达的上调；高脂肪饲料（HFD）诱导小鼠肥胖后则导致脂肪组织 Cdo1 表达的下降。 前人研究表明，Cdo1 在小鼠脂肪组织、肝脏等器官存在较高水平的表达。Cdo1 的全身性敲除小鼠出生后出现一定比例的死亡，存活下来的小鼠会表现为发育不良、骨骼弯曲、生长迟缓，这说明 Cdo1 对于机体的生长发育及正常生命活动十分重要。在 3T3-L1 脂肪细胞中，转录因子 PPARγ 和 C/EBPα 可以结合到 Cdo1 启动子上 [4]。这一研究提示 Cdo1 在脂肪组织中可能发挥着重
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