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- 2026年01月30日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Recombinant Human HMGB1/HMG1
- 规格：
10ug/50ug/500ug/1mg
| 规格： | 10ug | 产品价格： | ￥1024.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥3080.0 |
| 规格： | 500ug | 产品价格： | 询价 |
| 规格： | 1mg | 产品价格： | 询价 |
产品说明(Description)
Recombinant Human High Mobility Group Protein B1 is produced by our Mammalian expression system and the target gene encoding Gly2-Glu215 is expressed with a 6His tag at the C-terminus.
Accession #: P09429
Known as: High Mobility Group Protein B1; High Mobility Group Protein 1; HMG-1; HMGB1; HMG1
制剂（Formulation）
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
质量控制（Quality Control）
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.
运输（Shipping）
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
保存（Storage）
Store at ≤-70°C, stable for 6 months after receipt.
Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Please minimize freeze-thaw cycles.
背景（Background）
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.
电泳(SDS-PAGE)
参考文献(Reference)
The role of HMGB1 in invasive Candida albicans infection. Jiaojiao Wang. et al. bioRxiv. 2020.
TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis. GANG LI. et al. International journal of molecular medicine. 2016.
Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro[J]. Sun Q. et al. Journal of neuroinflammation. 2014.
FOR RESEARCH USE ONLY
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