NRG1/NRG1-β1细胞因子,重组人神经调节蛋白1-β1

重组人神经调节蛋白1-β1 (NRG1-β1) 蛋白

货号：PRP1954

英文名称：Human NRG1 Beta1 Protein

产品概述

重组人神经调节蛋白1-β1 (NRG1-β1) 是一种高纯度、无标签的细胞因子蛋白，来源于大肠杆菌表达系统。该产品经严格质控验证，适用于细胞培养及相关体外功能研究，尤其在神经发育、神经传递及突触可塑性研究领域具有重要应用价值。

关键特性

• 来源：人源重组蛋白，氨基酸序列对应UniProt编号Q02297 (S20-K241)
• 表达系统：大肠杆菌
• 纯度：＞99%（SDS-PAGE检测）
• 分子量：24.04 kDa
• 蛋白长度：220个氨基酸
• 内毒素水平：＜1.0 EU/μg（LAL法测定）
• 生物活性：经MCF-7细胞增殖实验验证，ED₅₀为0.6730 ng/mL

应用领域

• 神经系统发育与功能研究
• EGFR/ERBB受体家族信号通路机制探索
• 细胞增殖与分化相关实验
• 癌症和精神疾病模型构建（如精神分裂症机制研究）

产品形式与复溶建议

本品为冻干粉形式，冻干缓冲液为无菌20 mM Tris，150 mM NaCl，pH 7.4。推荐使用配套复溶缓冲液（Reconstitution Buffer）复溶至浓度不低于100 µg/mL，后续可根据实验需求进一步稀释。

保存与运输

• 保存条件：冻干粉可在-20°C稳定保存1年；复溶后于2-8°C可保存1周；稀释后分装保存于-20°C或-80°C可维持3-6个月稳定性。
• 运输方式：冰袋运输（蓝冰）

注意事项

• 使用前请离心，避免粉末损失。
• 避免反复冻融，建议分装保存。
• 本品仅供科研使用，不适用于人体或临床诊断。

背景信息

神经调节蛋白1（NRG1）属于神经调节蛋白家族成员之一，可通过作用于表皮生长因子受体（EGFR/ERBB）家族参与多种生物学过程。NRG1在神经发育、神经传递及突触可塑性的调控中发挥关键作用，其异常表达与癌症、精神分裂症等疾病密切相关。该基因（Gene ID: 142445）编码多种异构体，具有广泛的生物学功能和研究价值。

规格与价格

规格	价格（元）	货期
10 μg	588	现货，次日发货
50 μg	1588	现货，次日发货
500 μg	8998	请咨询
1 mg	请咨询	请咨询

别名：ARIA, NRG1, GGF, HGL, HRG, HRGA, NDF, SMDF, Acetylcholine receptor-inducing activity, Glial growth factor, Heregulin, Neu differentiation factor, Sensory and motor neuron-derived factor

警告：本产品仅用于科学研究，不适用于诊断或人体用途。使用者应确保其应用不违反相关专利或许可证限制。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Recombinant Human Neuregulin 1-β1 (NRG1-β1) Protein

Catalog Number: PRP1954

Product Name: Human NRG1 Beta1 Protein

Product Overview

Recombinant Human Neuregulin 1-β1 (NRG1-β1) is a high-purity, tag-free cytokine protein produced in an E. coli expression system. This product undergoes rigorous quality control and is suitable for cell culture and related in vitro functional studies, particularly in the fields of neural development, neurotransmission, and synaptic plasticity research.

Key Features

• Source: Human recombinant protein, amino acid sequence corresponds to UniProt ID Q02297 (S20-K241)
• Expression System: E. coli
• Purity: >99% as determined by SDS-PAGE
• Molecular Weight: 24.04 kDa
• Protein Length: 220 amino acids
• Endotoxin Level: <1.0 EU/μg (determined by LAL assay)
• Biological Activity: ED₅₀ is 0.6730 ng/mL, as measured by MCF-7 cell proliferation assay

Applications

• Nervous system development and function research
• Mechanistic exploration of EGFR/ERBB receptor family signaling pathways
• Cell proliferation and differentiation-related experiments
• Model construction for cancer and psychiatric disorders (e.g., schizophrenia mechanism research)

Product Form and Reconstitution

This product is supplied as a lyophilized powder, lyophilized from a sterile 20 mM Tris, 150 mM NaCl buffer, pH 7.4. It is recommended to reconstitute to a concentration not less than 100 µg/mL using the accompanying Reconstitution Buffer, and it can be further diluted according to experimental needs.

Storage and Shipping

• Storage Conditions: The lyophilized powder is stable for 1 year when stored at -20°C; after reconstitution, it can be stored at 2-8°C for 1 week; for long-term storage, aliquot and store diluted samples at -20°C or -80°C for 3-6 months.
• Shipping Method: Shipped with ice packs (blue ice)

Precautions

• Centrifuge the vial prior to opening to avoid loss of powder.
• Avoid repeated freeze-thaw cycles; it is recommended to prepare aliquots.
• This product is for research use only, not intended for human or diagnostic use.

Background

Neuregulin 1 (NRG1) is a member of the neuregulin family. It acts via the Epidermal Growth Factor Receptor (EGFR/ERBB) family and is involved in various biological processes. NRG1 plays a key role in regulating neural development, neurotransmission, and synaptic plasticity. Its aberrant expression is closely associated with diseases such as cancer and schizophrenia. The gene (Gene ID: 142445) encodes multiple isoforms and possesses broad biological functions and research value.

Specifications and Pricing

Specification	Price (RMB)	Availability
10 μg	588	In stock, ships next day
50 μg	1588	In stock, ships next day
500 μg	8998	Please inquire
1 mg	Please inquire	Please inquire

Aliases: ARIA, NRG1, GGF, HGL, HRG, HRGA, NDF, SMDF, Acetylcholine receptor-inducing activity, Glial growth factor, Heregulin, Neu differentiation factor, Sensory and motor neuron-derived factor

Warning: This product is for research use only and is not intended for diagnostic or human use. Users should ensure their application does not infringe upon relevant patents or license restrictions.

Note: The above information is subject to change due to factors such as product optimization and upgrades. For specific details, please contact YaKeyin Company.