- ￥588 - 4698
- 亚科因(Abbkine)
- PRP1900-3
- 湖北武汉
- 2025年12月31日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
999
- 供应商：
亚科因(Abbkine)
- 英文名：
Human IL-11 Protein, His tag (Animal-Free)
- 规格：
5 μg/20 μg/100 μg/1 mg
| 规格： | 5 μg | 产品价格： | ￥588.0 |
|---|---|---|---|
| 规格： | 20 μg | 产品价格： | ￥1498.0 |
| 规格： | 100 μg | 产品价格： | ￥4698.0 |
| 规格： | 1 mg | 产品价格： | 询价 |
产品概述
本品为高纯度、高活性重组人白细胞介素-11（IL-11）蛋白，携带His标签，且生产过程中无动物源成分。专为严谨的细胞培养及生物医学研究设计，具备卓越的批次间一致性和可靠的实验表现。
核心特性
- 高生物活性：经功能验证，其诱导T11细胞增殖的ED₅₀值<0.2 ng/mL，特异性活性约大于1 × 10⁷ IU/毫克，确保在细胞实验中的高效能。
- 超高纯度：经SDS-PAGE分析，纯度大于98%，为实验结果的可重复性提供坚实基础。
- 极低内毒素：LAL法检测显示，每微克蛋白内毒素含量< 0.1 EU，尽可能降低对细胞实验的非特异性干扰。
- 无动物源生产：在无动物源成分的体系中表达，有效规避动物源病原体风险，适用于对来源有严格要求的应用场景。
产品详情
| 产品名称 | IL-11 重组人白介素-11 人源重组蛋白 细胞因子 | 英文名称 | Human IL-11 Protein, His tag (Animal-Free) |
|---|---|---|---|
| 货号 | PRP1900 | 表达宿主 | 大肠杆菌 |
| 种属来源 | 人 | 蛋白长度 | 19.95 kDa (计算值)，SDS-PAGE显示约24 kDa |
| 序列信息 | 基于UniProt登录号P20809（人IL-11），对应氨基酸序列Pro22-Leu199，N端融合6×His标签。 | ||
| 产品形式 | 冻干粉，由1X PBS (pH 8.0)缓冲液经0.2 µm过滤后冻干而成。 | ||
背景信息
白细胞介素-11（IL-11）是gp130细胞因子家族的成员，最初因其在造血系统（特别是促进巨核细胞成熟和血小板生成）中的关键作用而被广泛认知。它通过介导gp130:IL-11:IL-11 RA复合物的二聚化来发挥其广泛的生物学功能，亦被称为脂肪生成抑制因子（AGIF），在骨骼代谢、神经保护和黏膜修复等生理病理过程中也扮演着重要角色。
使用指南
- 复溶：开盖前请先离心。建议使用我们提供的专用复溶缓冲液（Reconstitution Buffer），将冻干粉复溶至浓度不低于100 µg/mL的储存液，后续可根据实验需求进行稀释。
- 保存：冻干粉在-20°C下可稳定保存1年。复溶后于2-8°C可保存1周。若在含有载体蛋白（如0.1% BSA）的缓冲液中进一步稀释，分装后于-20°C或-80°C下可保存3-6个月，应避免反复冻融。
- 运输：本品采用蓝冰冰袋运输，以确保产品在途中的稳定性。
规格与价格
| 规格 | 价格 (人民币) | 货期 |
|---|---|---|
| 5 μg | 588 | 现货，次日发货 |
| 20 μg | 1498 | 现货，次日发货 |
| 100 μg | 4698 | 请咨询 |
| 1 mg | 请咨询 | 请咨询 |
重要提示：本产品仅供研究使用，不适用于人类或临床诊断。使用者应确保其应用不违反任何专利或许可证规定。
注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。
Product Overview
This product is a high-purity, high-activity recombinant human Interleukin-11 (IL-11) protein with a His tag, produced without any animal-derived components. It is designed for rigorous cell culture and biomedical research, offering exceptional lot-to-lot consistency and reliable experimental performance.
Key Features
- High Bioactivity: Functionally validated, its ED₅₀ for inducing T11 cell proliferation is <0.2 ng/mL, with a specific activity approximately >1 × 10⁷ IU/mg, ensuring high efficacy in cellular assays.
- Ultra-High Purity: Purity exceeds 98% as determined by SDS-PAGE analysis, providing a solid foundation for reproducible experimental results.
- Ultra-Low Endotoxin: Endotoxin level is < 0.1 EU per µg of protein as measured by LAL assay, minimizing non-specific interference in cell-based experiments.
- Animal-Free Production: Expressed in an animal component-free system, effectively avoiding the risk of animal-derived pathogens, suitable for applications with stringent source requirements.
Product Details
| Product Name | IL-11 Recombinant Human Interleukin-11 Human Recombinant Protein Cytokine | English Name | Human IL-11 Protein, His tag (Animal-Free) |
|---|---|---|---|
| Catalog Number | PRP1900 | Expression Host | E. coli |
| Species Origin | Human | Protein Length | 19.95 kDa (Calculated), ~24 kDa as observed by SDS-PAGE |
| Sequence Information | Based on UniProt Accession P20809 (Human IL-11), corresponding to amino acids Pro22-Leu199, with an N-terminal 6×His tag fusion. | ||
| Product Form | Lyophilized powder, lyophilized from a 0.2 µm filtered solution in 1X PBS (pH 8.0). | ||
Background
Interleukin-11 (IL-11), a member of the gp130 cytokine family, was initially widely recognized for its pivotal role in the hematopoietic system, particularly in promoting megakaryocyte maturation and platelet production. It exerts its broad biological functions by mediating the dimerization of the gp130:IL-11:IL-11 RA complex. Also known as Adipogenesis Inhibitory Factor (AGIF), it plays significant roles in physiological and pathological processes such as bone metabolism, neuroprotection, and mucosal repair.
Usage Guidelines
- Reconstitution: Centrifuge the vial before opening. It is recommended to reconstitute the lyophilized powder with the provided dedicated Reconstitution Buffer to a stock concentration of not less than 100 µg/mL, which can be further diluted according to experimental needs.
- Storage: The lyophilized powder is stable for 1 year at -20°C. After reconstitution, it can be stored at 2-8°C for 1 week. If further diluted in a buffer containing a carrier protein (e.g., 0.1% BSA), aliquot and store at -20°C or -80°C for 3-6 months, avoiding repeated freeze-thaw cycles.
- Shipping: This product is shipped with blue ice packs to ensure stability during transit.
Specifications & Pricing
| Specification | Price (RMB) | Lead Time |
|---|---|---|
| 5 μg | 588 | In stock, ships next day |
| 20 μg | 1498 | In stock, ships next day |
| 100 μg | 4698 | Please inquire |
| 1 mg | Please inquire | Please inquire |
Important Note: This product is for research use only, not intended for human or clinical diagnostic use. Users should ensure their application does not violate any patent or licensing regulations.
Note: The above information is subject to change due to factors such as product optimization and upgrades. Please consult Yakyn for specific details.
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编号：200-13)的说明书中您会看到：Slow to dissolve (缓慢溶解)，在重组人IL-11(产品编号：200-11)的说明中会看到： This solution is slow to dissolve.(该溶液溶解缓慢)。这种情况下，您最好能将要溶解的细胞因子或重组蛋白放在水平摇床(shaker)上低速摇一段时间，促使细胞因子或重组蛋白完全溶解。 有些蛋白，如重组人IL-13 Variant (产品编号：200-13A)虽然难溶，但却不需用摇床来加速溶解。其说明书上的备注
的完全溶解，该怎么办呢？ 答：多数细胞因子或重组蛋白的冻干粉是非常容易溶解的，一般我们用移液枪的枪头轻吹几下，即可使细胞因子或重组蛋白完全溶解。 对于不易溶解的细胞因子或蛋白，PeproTech会在说明书中进行备注(Note)。如在重组人IL-13(产品编号：200-13)的说明书中您会看到：Slow to dissolve (缓慢溶解)，在重组人IL-11(产品编号：200-11)的说明中会看到： This solution is slow to dissolve.(该溶液溶解缓慢
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