- 询价
- BIO-RAD
- TZA093SBV670
- 2025年12月11日
- F
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Mammalian cells transfected with full length CD186
- 亚型：
IgG1
- 形态：
Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain and conjugated to StarBright Violet 670 – liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
StarBright Violet 670
- 适应物种：
Human
- 保质期：
自发货之日起 12 个月
- 目录编号：
rD02-7B3
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
F
- 浓度：
For information on the concentration of our StarBright Dye conjugated reagents please visit our FAQ page.
- 抗体名：
CD186 antibody | rD02-7B3
- 规格：
100 Tests/0.5ml
CD186 is a 39kDa G protein-coupled chemokine receptor which is expressed on CD4+ T cells, NK cells and plasma cells, as well as lymphoid tissues. It is expressed at a very low level on naïve CD8+ T cells, with expression upregulated after activation. Through interactions with its ligand CXCL16, CD186 is involved in chemotaxis, aiding in immune responses by recruiting cells to sites of inflammation.
CD186 acts as a co-receptor for m-tropic HIV-1 and SIVs in conjunction with CD4. Dysfunction or altered expression of CD186 has been linked to several autoimmune and inflammatory diseases. In rheumatoid arthritis, elevated expression is found in T cells found in synovial fluid, where it is implicated in disease pathogenesis by inducing T-lymphocyte homing to the joints and Th1 polarization. Expression is also upregulated on T cells in the colons of patients with Crohn’s disease. CD8+ T cell trafficking to the skin in vitiligo patients is mediated by CD186-CXCL16 interactions.
储存信息
This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
应用
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | Neat |
Flow Cytometry
Use 5μl of the suggested working dilution to label 106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
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