- 询价
- BIO-RAD
- MCA74SBUV540
- 2025年12月11日
- F
- Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
T cell enriched splenocytes from B10 mice.
- 亚型：
IgG2b
- 形态：
Purified IgG conjugated to StarBright UltraViolet 540 - liquid
- 克隆性：
Monoclonal Antibody
- 标记物：
StarBright UltraViolet 540
- 适应物种：
Mouse
- 保质期：
自发货之日起 12 个月
- 目录编号：
M1/70.15
- 供应商：
伯乐生命医学产品（上海）有限公司
- 应用范围：
F
- 浓度：
For information on the concentration of our StarBright Dye conjugated reagents please visit our FAQ page.
- 抗体名：
CD11b antibody | M1/70.15
- 规格：
100 Tests/0.5ml
Rat anti Mouse CD11b antibody, clone M1/70.15 recognizes the murine CD11b cell surface antigen also known as the alpha M integrin chain or MAC-1, a differentiation antigen expressed by granulocytes, monocytes, NK cells and tissue macrophages.
The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages.
Rat anti Mouse CD11b antibody, clone M1/70.15 has been reported to block iC3b binding to its receptor (Beller et al. 1982).
Rat anti Mouse CD11b antibody, clone M1/70.15 has been reported to as being suitable for use on PLP fixed paraffin embedded tissue but has not been tested for use on formalin fixed tissue (Whiteland et al. 1995).
This product is routinely tested in flow cytometry on mouse peritoneal macrophages.
The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages.
Rat anti Mouse CD11b antibody, clone M1/70.15 has been reported to block iC3b binding to its receptor (Beller et al. 1982).
Rat anti Mouse CD11b antibody, clone M1/70.15 has been reported to as being suitable for use on PLP fixed paraffin embedded tissue but has not been tested for use on formalin fixed tissue (Whiteland et al. 1995).
This product is routinely tested in flow cytometry on mouse peritoneal macrophages.
储存信息
Store at +4°C. DO NOT FREEZE.
This product should be stored undiluted.
This product should be stored undiluted.
应用
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry | ✓ | Neat |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 5μl of the suggested working dilution to label 106 cells in 100μl. Best practices suggest a 5 minutes centrifugation at 6,000g prior to sample application.
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文献和实验该产品被引用文献
Source Reference
- Springer, T. et al. (1978) Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens.
Eur J Immunol. 8 (8): 539-51.
Antibody Characterization Reference
- Springer, T. et al. (1979) Mac-1: a macrophage differentiation antigen identified by monoclonal antibody.
Eur J Immunol. 9 (4): 301-6.
References for CD11b antibody
- Beller, D.I. et al. (1982) Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.
J Exp Med. 156 (4): 1000-9. - Whiteland, J.L. et al. (1995) Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.
J Histochem Cytochem. 43 (3): 313-20. - Welt, F.G. et al. (2000) Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries.
Arterioscler Thromb Vasc Biol. 20 (12): 2553-8. - Kapturczak, M.H. et al (2004) Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.
Am J Pathol. 165: 1045-53. - Patel, P.C. and Harrison, R.E. (2008) Membrane ruffles capture C3bi-opsonized particles in activated macrophages.
Mol Biol Cell. 19: 4628-39. - Huang, Q.Q. et al (2008) Role of H2-calponin in regulating macrophage motility and phagocytosis.
J Biol Chem. 283: 25887-99. - Brochard, V. et al (2009) Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
J Clin Invest. 119: 182-92. - Hudcovic, T. et al (2009) Monocolonization with Bacteroides ovatus protects immunodeficient SCID mice from mortality in chronic intestinal inflammation caused by long-lasting dextran sodium sulfate treatment.
Physiol Res. 58: 101-10.
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Rat anti Mouse CD11b:StarBright UltraViolet 540，clone M1/70.15
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