- 询价
- Miltenyi Biotec
- 德国
- 130-132-316
- 2025年12月09日
- MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
SLC12A5 (KCC2)
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REAL1126
- 标记物：
Vio B515
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
cell line
- 应用范围：
MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 抗体英文名：
SLC12A5 (KCC2) Antibody, anti-human, REAdye_lease™
- 抗体名：
SLC12A5 (KCC2) Antibody, anti-human, REAdye_lease™
- 规格：
200 µL
Detection of SLC12A5 (KCC2)+ cellsClone REAL1126 is an antibody fragment derived from the full SLC12A5 (KCC2) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity | Clone REAL1126 recognizes SLC12A5 (KCC2), a neuron-specific membrane protein expressed throughout the central nervous system, including the hippocampus, hypothalamus, brainstem, and motoneurons of the ventral spinal cord. It is a critical mediator of synaptic inhibition, cellular protection against excitotoxicity and may also act as a modulator of neuroplasticity. SLC12A5 mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl- homeostasis. It is involved in the regulation of dendritic spine formation and maturation. KCC2 deficiency might play a role in the pathogenesis human epilepsy. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
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文献和实验该产品被引用文献
Puskarjov, M. et al. (2014) A variant of KCC2 from patients with febrile seizures impairs neuronal Cl− extrusion and dendritic spine formation. EMBO J. 15 (6): 723–729. | Liu, R. et al. (2020) Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function. Front Neurol 10: doi: 10.3389/fneur.2019.01407. | Wan, L. et al. (2020) Coordinated downregulation of KCC2 and GABA(A) receptor contributes to inhibitory dysfunction during seizure induction. Biochem. Biophys. Res. Commun. 532 (3): 489–495.
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SLC12A5 (KCC2) Antibody, anti-human, Vio® B515, REAdye_lease™, 200 µL
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