- 询价
- Miltenyi Biotec
- 德国
- 130-137-259
- 2025年12月09日
- MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD44
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REAL215
- 标记物：
Vio R667
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
cell line
- 应用范围：
MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 抗体英文名：
CD44 Antibody, anti-mouse, REAdye_lease™
- 抗体名：
CD44 Antibody, anti-mouse, REAdye_lease™
- 规格：
200 µL
Detection of CD44+ cellsClone REAL215 is an antibody fragment derived from the full CD44 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity | Clone REAL215 recognizes the mouse CD44 antigen, which is also known as Pgp-1, HCELL, HUTCH-I, HCAM, HERMES, and Ly-24. CD44 is a 80–95 kDa membrane glycoprotein and is expressed by a variety of hematopoetic and nonhematopoetic cells. Different isoforms are generated by alternative splicing. Clone REA664 reacts with all isoforms and both allelic forms of CD44. CD44 functions as a receptor for hyaluronic acid (HA) and mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). The interaction between Galectin-9 and CD44 increases the stability and function of adaptive regulatory T cells. CD44 expression is upregulated on naive T cells upon activation and high CD44 expression is maintained on memory T cells. Therefore, CD44 is often used to discriminate CD44hi antigen-experienced T cells from CD44low (CD62L+) naive T cells. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
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文献和实验该产品被引用文献
He, Q. et al. (1992) Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J. Cell Biol. 119 (6): 1711–1719. | Ponta, H. et al. (2003) CD44: From adhesion molecules to signalling regulators. Nat. Rev. Mol. Cell Biol. 4 (1): 33–45. | Wu, C. et al. (2014) Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 41 (2): 270–282.
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CD44 Antibody, anti-mouse, Vio® R667, REAdye_lease™, 200 µL
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