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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD94
- 亚型:
recombinant human IgG1
- 形态:
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件:
避光,4-8℃
- 克隆性:
REA1186
- 标记物:
PE-Vio 615
- 适应物种:
mouse
- 保质期:
24个月
- 供应商:
Miltenyi biotec
- 宿主:
human cell line
- 应用范围:
Flow cytometry
- 浓度:
1:50
- 抗体英文名:
CD94 Antibody, anti-mouse, REAfinity™
- 抗体名:
CD94 Antibody, anti-mouse, REAfinity™
- 规格:
150 µg in 1 mL
Identification and enumeration of CD94+ cells by flow cytometryClone REA1186 recognizes the murine CD94 antigen, an approximately 70 kDa single-pass type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8+ cells in most mouse strains. DBA/2J mice do not express CD94. | Additional information: Clone REA1186 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Vance, R. E. et al. (1997) Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur. J. Immunol. 27 (12): 3236–3241. | Ho, E. L. et al. (1998) Murine Nkg2d and CD94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6320–6325.
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CD94 Antibody, anti-mouse, PE-Vio® 615, REAfinity™, 150 µg in 1 mL
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