- 询价
- Miltenyi Biotec
- 德国
- 130-101-089
- 2025年12月09日
- Functional assay, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Functional assay
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD89
- 亚型：
recombinant human IgG1
- 形态：
Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
- 保存条件：
避光，4-8℃
- 克隆性：
REA234
- 标记物：
pure-functional grade
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi biotec
- 宿主：
human cell line
- 应用范围：
Functional assay, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Functional assay
- 抗体英文名：
CD89 Antibody, anti-human, REAfinity™
- 抗体名：
CD89 Antibody, anti-human, REAfinity™
- 规格：
500 µg in 0.5 mL
Unconjugated antibody for functional assaysClone REA234 recognizes CD89, the human myeloid IgA Fc receptor. CD89 is a glycosylated transmembrane protein that binds both IgA subclasses (IgA1 and IgA2) and is closely related to the KIR and MIR proteins rather than to other human Fc receptors. CD89 itself lacks the canonical signal transduction domains, however it associates with the FcR γ-chain with an immunoreceptor tyrosine-based activation (ITAM) motif, which allows transduction of activation signal upon ligand binding. FcαRI alone mediates endocytosis and recyling of IgA. Expression of CD89 is found on neutrophils, eosinophils, monocytes/macrophages, dendritic cells, and Kupffer cells. | Additional information: Clone REA234 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Wu, J. et al. (2007) FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol 178: 3973–3982. | Morton, H. C. et al. (1995) Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR chain. J. Biol. Chem. 270: 29781–29787.
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CD89 Antibody, anti-human, pure-functional grade, REAfinity™, 500 µg in 0.5 mL
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