IL-13 Antibody, anti-human, AP

Identification and enumeration of IL-13+ cells by flow cytometryClone REA1011 recognizes the interleukin-13 (IL-13), which is produced primarily by activated Tʜ2 cells, but also by mast cells, natural killer (NK) cells, and dendritic cells (DCs). IL-13 exerts anti-inflammatory effects on monocytes and macrophages. Furthermore, it inhibits the expression of pro-inflammatory cytokines, such as IL-1β, TNF-α, IL-6, and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in an increased production of IgE. IL-13, in contrast to IL-4, fails to induce Tʜ2 cell differentiation, one of the hallmarks of the allergic response. | Additional Information: Clone REA1011 displays negligible binding to Fc receptors.