CD44H Antibody, anti-rat, FITC

Identification and enumeration of CD44H+ cells by flow cytometryClone REA505 recognizes the rat CD44H antigen, a transmembrane glycoprotein, also known as homing-associated cell adhesion molecule (H-CAM) or phagocytic glycoprotein-1 (Pgp-1). CD44H belongs to the CD44 group, that encompasses several isoforms expressed in a variety of tissues. It is highly expressed on hematopoietic and non-hematopoietic cells. All isoforms are encoded by the same gene on chromosome 11 and are formed by alternative splicing of their mRNA. CD44 isoforms belong to the family of cell adhesion molecules and to the sub-family of the hyaladherins in consideration of their affinity for hyaluronate and their structural homology with the cartilage link protein. The standard form of CD44, CD44H, exhibits a high affinity for hyaluronate, plays a role in the uptake and degradation of this glycosaminoglycan, and participates in cell locomotion in its presence. | Additional information: Clone REA505 displays negligible binding to Fc receptors.