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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
CD4 (Domain 1)
- 亚型:
recombinant human IgG1
- 形态:
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件:
避光,4-8℃
- 克隆性:
REA482
- 标记物:
PE
- 适应物种:
rat
- 保质期:
24个月
- 供应商:
Miltenyi Biotec
- 宿主:
human cell line
- 应用范围:
Flow cytometry
- 浓度:
1:10
- 抗体英文名:
CD4 (Domain 1) Antibody, anti-rat, REAfinity™
- 抗体名:
CD4 (Domain 1) Antibody, anti-rat, REAfinity™
- 规格:
9 µg in 300 µL
Identification and enumeration of CD4 (Domain 1)+ cells by flow cytometryClone REA482 recognizes domain 1 of the rat CD4 antigen, a single-pass type I membrane protein also known as T cell surface antigen T4/Leu-3 or W3/25 antigen. CD4 is a member of the immunoglobulin superfamily and is expressed on the surface of T helper cells, monocytes, macrophages, and dendritic cells. It has four immunoglobulin domains (D1 to D4). D1 and D3 resemble immunoglobulin variable (IgV) domains, and D2 and D4 resemble immunoglobulin constant (IgC) domains. CD4 is a co-receptor that assists the T cell receptor (TCR) in communicating with an antigen-presenting cell (APC). CD4 amplifies the signal generated by the TCR by recruiting the tyrosine kinase Lck, which is essential for activating many molecular components of the signaling cascade of an activated T cell. CD4 also interacts directly with MHC class II molecules on the surface of APCs. | Additional information: Clone REA482 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Clark, S. J. et al. (1987) Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc. Natl. Acad. Sci. U.S.A. 84 (6): 1649–1653. | Jin, H. et al. (2013) CD4+CD25+Foxp3+ T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma. Int. Immunopharmacol. 15 (1): 42–49. | Almolda, B. et al. (2009) CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model. J. Neuroimmunol. 209 (1-2): 65–80.
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CD4 (Domain 1) Antibody, anti-rat, PE, REAfinity™, 9 µg in 300 µL
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