- 询价
- Miltenyi Biotec
- 德国
- 130-110-650
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD39
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA739
- 标记物：
PE
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD39 Antibody, anti-human, REAfinity™
- 抗体名：
CD39 Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD39+ cells by flow cytometryClone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells. | Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells. | Additional information: Clone REA739 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol 153 (8): 3574–3583. | Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271 (51): 33116–33122. | Borsellino, G. et al. (2007) Expression of ectonucleotidase CD39 by FoxP3+ reg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225–1232.
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CD39 Antibody, anti-human, PE, REAfinity™, 100 tests in 200 µL
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