CD326 (EpCAM) Antibody, anti-h

Recombinant antibody for the detection of CD32+ cellsClone REA1311 recognizes the pleiotropic molecule CD326, which is also known as epithelial cell adhesion molecule (EpCAM). It is involved in cell adhesion and mediates intercellular adhesion and associates with the actin cytoskeleton. The CD326 antigen is an useful diagnostic marker for epithelia and epithelial-derived neoplasm. It is found in metastases, malignant effusions, and cancer stem cells. It is overexpressed in certain carcinomas including colon, pancreas, breast and most adenocarcinomas. It is not detected on melanoma, neuroblastoma, sarcoma, lymphoma, leukemia cells, or normal fibroblasts. Furthermore, it is suggested, that CD326 could be used as a surface marker for human ESCs. | Additional information: Clone REA1311 displays negligible binding to Fc receptors.