- 询价
- Miltenyi Biotec
- 德国
- 130-129-483
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD319 (CRACC)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA150
- 标记物：
PE-Vio 615
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD319 (CRACC) Antibody, anti-human, REAfinity™
- 抗体名：
CD319 (CRACC) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of CD319 (CRACC)+ cells by flow cytometryClone REA150 recognizes CD319, which is a single-pass type I transmembrane protein. CD319 belongs to the SLAM-related receptors (SRRs) family, a subgroup of the CD2 family of Ig-like receptors. Expression of CD319 is found on activated B lymphocytes, natural killer (NK) cells, CD8+T lymphocytes, and mature dendritic cells. The cytoplasmic domain of CD319 contains immunoreceptor tyrosine-based switch motifs (ITSMs), which provide the docking sites for recruitment of small SH2-containing adapter proteins, such as SH2D1A/SLAM-associated protein (SAP) and EWS activated transcript 2 (EAT-2). CD319 displays homophilic interaction and is involved in mediating NK cell cytotoxicity, in the absence of an inhibitory receptor engagement. | Additional information: Clone REA150 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Lee, J. K. et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol 179 (7): 4672–4678. | Tassi, I. et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase C signaling pathways in human NK cells. J Immunol 175: 7996–8002. | Lee, J. K. et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur. J. Immunol. 34 (10): 2791–2799.
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CD319 (CRACC) Antibody, anti-human, PE-Vio® 615, REAfinity™, 30 tests in 60 µL
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