文献支持
CD278 (ICOS) Antibody, anti-hu
man/mouse/rat, PE-Vio® 770, REAfinity™, 100 tests in 200 µL- 询价
- Miltenyi Biotec
- 德国
- 130-127-963
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- human cell line
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD278 (ICOS)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA192
- 标记物：
PE-Vio 770
- 适应物种：
human, mouse, rat
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
CD278 (ICOS) Antibody, anti-human/mouse/rat, REAfinity™
- 抗体名：
CD278 (ICOS) Antibody, anti-human/mouse/rat, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD278 (ICOS)+ cells by flow cytometryClone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are costimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes inducible T cell costimulator ligand (ICOSL) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by costimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching. | Additional information: Clone REA192 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Akbari, O. et al. (2008) ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol 180: 5448–5456. | Wassink, L. et al. (2004) ICOS expression by activated human Tʜ Cells is enhanced by IL-12 and IL-23: Increased ICOS expression enhances the effector function of both Tʜ1 and Tʜ2 cells. J Immunol 173: 1779–1786.
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CD278 (ICOS) Antibody, anti-human/mouse/rat, PE-Vio® 770, REAfinity™, 100 tests in 200 µL
询价
