- 询价
- Miltenyi Biotec
- 德国
- 130-132-443
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD222
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，4-8℃
- 克隆性：
REA187
- 标记物：
FITC
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
CD222 Antibody, anti-human, REAfinity™
- 抗体名：
CD222 Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of CD222+ cells by flow cytometryClone REA187 recognizes CD222, a 300 kDa type I transmembrane protein, which serves as a multifunction receptor and is ubiquitously expressed. CD222 has a large extracytoplasmic domain, a single transmembrane region, and a short cytoplasmic tail that lacks intrinsic catalytic activity. The receptor cycles continuously between intracellular compartments and the plasma membrane. At steady state, CD222 is found mainly intracellularly, and to a lesser extent on the cell surface. CD222 binds IGF-2 and mannose-6 phosphate containing ligands such as transforming growth factor‐β, leukemia inhibitory factor, and proliferin. This interaction allows CD222-mediated regulation of ligand dependent signaling and uptake and cellular processing of ligands. CD222 is further suggested to function as the cation-independent cell surface receptor for heparanase. Interaction of heparanase with various cell surfaces is suggested to be important for heparanse functions. Cell surface displayed heparanase allows efficient degaradation of local extracellular matrix (ECM)/basement membrane (BM) components. | Additional information: Clone REA187 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Leksa, V. et al. (2012) Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells. J. Biol. Chem. 287: 22450–22462. | Wood, R. J. et al. (2008) Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation. J. Biol. Chem. 283: 4165–4176.
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CD222 Antibody, anti-human, FITC, REAfinity™, 100 tests in 200 µL
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