CD186 (CXCR6) Antibody, anti-m

Identification and enumeration of CD186 (CXCR6)+ cells by flow cytometryClone REA1193 recognizes the mouse CD186 chemokine receptor, which is also known as Cxcr6 (receptor for the C-X-C chemokine CXCL16). CD186 is expressed by naive CD8 T cells, natural killer T cells, and a subset of memory CD4 T cells. | The chemokine CXCL16 is produced by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. It is reported, that CXCL16 plays a role in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp.Furthermore, CXCL16 and CXCR6 play an essential role in the maintenance of cardiac allograft tolerance mediated by NKT cells. | Additional information: Clone REA1193 displays negligible binding to Fc receptors.