- 询价
- Miltenyi Biotec
- 德国
- 130-102-583
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
CD123
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA114
- 标记物：
PE
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 抗体英文名：
CD123 Antibody, anti-mouse, REAfinity™
- 抗体名：
CD123 Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 1 mL
Identification and enumeration of CD123+ cells by flow cytometryClone REA114 recognizes CD123, the alpha chain of the IL-3 receptor. CD123 is 60–70 kDa membrane glycoprotein and interacts in mice with common beta chain (betac) and beta IL-3 subunits to form functional heterodimeric IL-3 receptors. CD123 alone can bind IL-3 with low affinity, however a high affinity binding is displayed by the heterodimeric forms. Besides ligand binding, the alpha chain of IL-3R was also shown to be necessary for the activation of STAT-5. Expression of CD123 is widely found in hematopoietic cells and in addition on basophils, mast cells, and megakaryocytes. AKR, RF, A/J, and NZB mouse strains carry a 5-bp deletion in the IL-3Ra gene and thus lack the expression of CD123. | Additional information: Clone REA114 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Hara, T. et al. (1995) Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood 85: 2331–2336. | Reddy, E. P. et al. (2000) IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled. Oncogene 19 (21): 2532–2547. | Lehmann, C. et al. (2014) Longitudinal analysis of distribution and function of plasmacytoid dendritic cells in peripheral blood and gut mucosa of HIV infected patients. J. Infect. Dis. 209: 940–949.
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CD123 Antibody, anti-mouse, PE, REAfinity™, 30 µg in 1 mL
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