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Ly-49A/D Antibody, anti-mouse,

APC-Vio® 770, REAfinity™, 150 µg in 1 mL
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  • 询价
  • Miltenyi Biotec已认证
  • 德国
  • 130-112-753
  • 2025年12月09日
  • Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
  • human cell line
  • mouse
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      Ly-49A/D

    • 亚型

      recombinant human IgG1

    • 形态

      Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.

    • 保存条件

      避光,2-8℃

    • 克隆性

      REA853

    • 标记物

      APC-Vio 770

    • 适应物种

      mouse

    • 保质期

      24个月

    • 供应商

      Miltenyi Biotec

    • 宿主

      human cell line

    • 应用范围

      Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry

    • 浓度

      1:50

    • 抗体英文名

      Ly-49A/D Antibody, anti-mouse, REAfinity™

    • 抗体名

      Ly-49A/D Antibody, anti-mouse, REAfinity™

    • 规格

      150 µg in 1 mL

    Identification and enumeration of Ly-49A/D+ cells by flow cytometryClone REA853 recognizes the mouse Ly-49A and Ly-49D antigens belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK T cells. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. | Clone REA853 does not react with BALB/c, DBA/2, AKR, or CBA/J Ly-D49D. | Additional information: Clone REA853 displays negligible binding to Fc receptors.

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    图标文献和实验
    该产品被引用文献
    Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613–635. | Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119–2128. | Takei, F. et al. (1997) The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155: 67–77. | Ortaldo, J. R. et al. (1998) The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol 160 (3): 1158–1165. | Ortaldo, J. R. et al. (1999) Ly-49 receptor expression and functional analysis in multiple mouse strains. J Leukoc Biol 66 (3): 512–520. | Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11 (1): 67–77. | Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J Immunol 165: 6922–6932.
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    文献支持
    Ly-49A/D Antibody, anti-mouse, APC-Vio® 770, REAfinity™, 150 µg in 1 mL
    询价