- 询价
- Miltenyi Biotec
- 德国
- 130-125-588
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
FoxP3
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA1253
- 标记物：
APC
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
FoxP3 Antibody, anti-human, REAfinity™
- 抗体名：
FoxP3 Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of FoxP3+ cells by flow cytometryClone REA1253 recognizes the FoxP3 antigen, the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression. | Additional information: Clone REA1253 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151–1164. | Hori, S. et al. (2003) Control of regulatory T cell development by the transcription factor FoxP3. Science 299: 1057–1061. | Walker, M. R. et al. (2003) Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J. Clin. Invest. 112: 1437–1443. | Jaeckel, E. et al. (2005) Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54: 306–310. | Gavin, M. A. et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. U.S.A. 103: 6659–6664. | Ziegler, S. F. (2006) FoxP3: of mice and men. Annu. Rev. Immunol. 24: 209–226.
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FoxP3 Antibody, anti-human, APC, REAfinity™, 30 tests in 60 µL
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