- 询价
- Miltenyi Biotec
- 德国
- 130-106-902
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 技术资料
- 免疫原：
ChemR23 (CMKLR1)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA461
- 标记物：
PE
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 靶点：
ChemR23 (CMKLR1)
- 抗体英文名：
ChemR23 (CMKLR1) Antibody, anti-mouse, REAfinity™
- 抗体名：
ChemR23 (CMKLR1) Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 1 mL
Identification and enumeration of ChemR23 (CMKLR1)+ cells by flow cytometryClone REA461 recognizes the mouse G-protein coupled receptor ChemR23 antigen, a multi-pass membrane protein, which is also known as chemokine-like receptor 1 (CMKLR1). During dendritic cell (DC) differentiation from bone marrow, ChemR23 is upregulated early and then diminishes with time in culture. Most DC in vivo do not detectably express the receptor. In contrast, freshly isolated F4/80+/CD11b+ mouse peritoneal macrophages express ChemR23, display calcium signaling and migration to the active ligand. A small population of blood-borne F4/80+/CD11b+ macrophages also expresses ChemR23. Its natural ligand, chemerin, acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation and phosphorylation of ERK-1/ERK-2 MAP kinases. ChemR23 positively regulates adipogenesis and adipocyte metabolism. | Additional information: Clone REA461 displays negligible binding to Fc receptors.
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ChemR23 (CMKLR1) Antibody, anti-mouse, PE, REAfinity™, 30 µg in 1 mL
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