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CCL5 (RANTES) Antibody, anti-h

uman, APC, REAfinity™, 100 tests in 200 µL
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  • 询价
  • Miltenyi Biotec已认证
  • 德国
  • 130-139-108
  • 2025年12月09日
  • Intracellular flow cytometry
  • human cell line
  • human, non-human primate
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      CCL5 (RANTES)

    • 亚型

      recombinant human IgG1

    • 形态

      Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.

    • 保存条件

      避光,2-8℃

    • 克隆性

      REA346

    • 标记物

      APC

    • 适应物种

      human, non-human primate

    • 保质期

      24个月

    • 供应商

      Miltenyi Biotec

    • 宿主

      human cell line

    • 应用范围

      Intracellular flow cytometry

    • 浓度

      1:50

    • 靶点

      CCL5 (RANTES)

    • 抗体英文名

      CCL5 (RANTES) Antibody, anti-human, REAfinity™

    • 抗体名

      CCL5 (RANTES) Antibody, anti-human, REAfinity™

    • 规格

      100 tests in 200 µL

    Identification and enumeration of CCL5 (RANTES)+ cells by flow cytometryClone REA346 recognizes the human C-C motif chemokine 5 (CCL5) antigen, a 8 kDa protein also known as RANTES (regulated on activation, normal T cell expressed and secreted). CCL5 belongs to the C-C chemokine family and is a target gene of NF-κB activity. It is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells. NF-κB activation by different stimuli such as CD40L or interleukin 15 (IL-15) induces CCL5 production. CCL5 plays an active role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and interferon γ (IFN-γ), CCL5 also induces the activation and proliferation of particular natural killer cells to generate C-C chemokine-activated killer cells. CCL5 produced by CD8+ T cells and other immune cells has been shown to inhibit HIV entry into target cells. CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5. CCR4 and CD44 are auxiliary receptors for CCL5. | Additional information: Clone REA346 displays negligible binding to Fc receptors.

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