- ￥361 - 4700
- MedChemExpress(MCE)
- 美国
- HY-12019
- 2025年12月06日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥791.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥361.0 |
| 规格： | 5 mg | 产品价格： | ￥1000.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥2950.0 |
| 规格： | 50 mg | 产品价格： | ￥4700.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
SGX-523
CAS No. : 1022150-57-7
MCE 国际站：SGX-523
产品活性：SGX523 是一种选择性和 ATP 竞争性的 MET 抑制剂。 SGX523 有效抑制 MET， IC50 为 4 nM ，比作用于其它他蛋白激酶的选择性高于 1,000 倍。具有抗肿瘤特性。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：c-Met/HGFR
In Vitro: SGX523 shows ATP-competitive inhibition with higher apparent affinity for the less active, unphosphorylated form of MET [MET-KD(0P), Ki=2.7 nM] versus the more active phospho-enzyme [MET-KD(3P), Ki=23 nM].
SGX523 inhibits the growth of gastric and lung cancer cell lines with amplification of the MET gene but has no effect, even at high micromolar concentration, on cell lines with normal MET gene copy number. TheIC50s of 0.02, 0.113, and 0.035 µM for NSCLC H1993, gastric cncer MKN45, and gastric cancer Hs746T cells, respectively.
The IC50 value for the inhibition of MET autophosphorylation is 0.040 μM in GTL16 cells.
SGX523 (0.5, 1.5, 4.6, 13.7, 41, 123, 370, 1100, 3300, 10000 nM; 1 hour) inhibits MET autophosphorylation without affecting total MET or extracellular signal-regulated kinase protein levels in HGF-stimulated A549 cells.
In Vivo: SGX523 exhibits antitumor activity in vivo. SGX523 inhibits MET-dependent tumor growth.
相关产品：Clinical Compound Library Plus | Bioactive Compound Library Plus | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Orally Active Compound Library | Anti-Lung Cancer Compound Library | Angiogenesis-Related Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Cytokine Inhibitors Library | Afatinib | Cabozantinib | Crizotinib | Capmatinib | Foretinib | Savolitinib | Tivantinib | Merestinib | PHA-665752 | BMS 777607 | SU11274 | JNJ-38877605 | Glesatinib hydrochloride | Golvatinib | Terevalefim | Amuvatinib | Ensartinib dihydrochloride | Altiratinib | Zanzalintinib | SRI 31215 TFA | Glumetinib | AMG-337 | Bozitinib | Elzovantinib | MK-2461 | PF-04217903 | SCR-1481B1 | Telisotuzumab vedotin
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验.18％。男1727例，阳性920例，阳性率53.3％；女1723例，阳性603例，阳性率51％。年龄分组见表1。 表1 年龄分组Hp阳性率 年龄组 检测例数 阳性例数 阳性率（％） ＜20 94 54 57.4 21～30 1029 497 48.3 31～40 979 506 51.7 41～50 547 277 50.6
General Considerations for Mouse Survival Surgery
. Biol. Rev. Camb. Philos. Soc. 57:487‐523. Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Division on Earth and Life Studies. 2011. Guide
后妇女因雌激素水平下降而引起的一系列症候群。临床应用以来，具有明显的抗骨质疏松，抗辐射以及改善内外生殖器官的局部条件，提高取器成功率，效果显著，是妇科安全、可靠、有效的药物。 参考文献 1 肖明星，郑景熙.“523”对同基因骨髓移植小鼠存活率及造血重建的影响.第一军医大学学报，96，16(1)：50～51 2 夏贞彪，王建国.“523”药物对受照小鼠造血系统的影响.中华放射医学与防护杂志，94，14(5)：322 3 赵文仲，沈建良.甾体雌激素在放射损伤性造血
技术资料暂无技术资料 索取技术资料
