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- 2025年12月06日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-20°C, stored under nitrogen
- 英文名：
(-)-Chicoric acid; trans-Caffeoyltartaric acid
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥596.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1312.0 |
| 规格： | 10 mg | 产品价格： | ￥2100.0 |
| 规格： | 25 mg | 产品价格： | ￥3688.0 |
| 规格： | 50 mg | 产品价格： | ￥5338.0 |
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L-Chicoric Acid
CAS No. : 70831-56-0
MCE 国际站：L-Chicoric Acid
产品活性：L-Chicoric Acid ((-)-Chicoric acid) 是一种二咖啡酰酒石酸，是一种有效的，选择性的和可逆的 HIV-1 整合酶 (HIV-1 integrase) 抑制剂，IC50 约为 100 nM。L-Chicoric Acid 还可抑制组织培养物中的 HIV-1 的复制。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：HIV Integrase | HIV | Endogenous Metabolite
结构分类：苯丙素类 | 简单苯丙素 | 酚类 | 多酚类 | 结构分类
In Vitro: L-Chicoric Acid inhibits integration at concentrations from 500 nM to 10 μM but also inhibits entry at concentrations above 1 μM. L-Chicoric Acid clearly affects viral entry at concentrations of 5 μM and higher. L-Chicoric Acid also inhibits integration as indicated both by an increased ratio of two LTR circle DNA to cDNA and an accompanying decrease in integrated provirus. The EC50 of L-Chicoric Acid against HIV is approximately 500 nM, a concentration that does not inhibit HIV entry in H9 cells.
The ED50 of L-Chicoric Acid against HIVNL4-3 control virus is 400 nM, while HIVNL4-3 passaged in the presence of 8 μM L-Chicoric Acid is completely resistant to the compound.
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