Chaetocin毛壳素,28097-03-2

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Chaetocin

CAS No. : 28097-03-2

MCE 国际站：Chaetocin

产品活性：Chaetocin是组蛋白甲基转移酶(HMT) SU(VAR)3-9的特异性抑制剂，IC₅₀值为0.6 μM。Chaetocin也可抑制硫氧还蛋白还原酶(TrxR)，IC₅₀值为4 μM。

研究领域：Epigenetics | Anti-infection

作用靶点：Histone Methyltransferase | Bacterial | Antibiotic

结构分类：生物碱 | 生物碱二聚体

In Vitro: Chaetocin is initially isolated from the fermentation broth of chaetomium minutum and belongs to the class of 3-6 epidithio-diketopiperazines (ETPs). The IC₅₀ for SU(VAR)3-9 is 0.6 μM and acts as a competitive inhibitor for S-adenosylmethionine. Chaetocin inhibits the human ortholog of dSU(VAR)3-9 with a similar IC₅₀ value of 0.8 μM. It inhibits other known Lys9-specific HMTs such as mouse G9a and Neurospora crassa DIM5 with a higher IC₅₀ values of 2.5 and 3 mM, respectively. Chaetocin inhibits TrxR1-initiated turnover of the synthetic substrate DTNB in a cell-free assay in a dose-responsive manner with an IC₅₀ of about 4 μM.

In Vivo: SL-2 Drosophila tissue cells are cultured in the presence or absence of the inhibitor. Chaetocin has a toxic effect on cells grown in culture. Toxicity is highly dependent on the initial cell density when chaetocin is added to the culture. The number of H3 molecules dimethylated at Lys9 (H3K9me2) is markedly reduced when cells are grown in medium containing 0.5 μM chaetocin after 5 d. Histones isolated from cells treated with 0.1 μM and for a shorter time also shows a drop in Lys9 methylation, but not as strongly as with the higher concentration.

相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Rapamycin | Doxorubicin hydrochloride | Chloroquine | Bafilomycin A1 | Puromycin dihydrochloride | Dexamethasone | Cycloheximide | Staurosporine | G-418 disulfate | Cyclosporin A | 5-Azacytidine | Doxycycline (hyclate) | Etoposide | Nigericin sodium salt | CCCP | Tazemetostat | Brefeldin A | Actinomycin D | Resveratrol | Wortmannin | Hygromycin B | Tunicamycin | Bleomycin sulfate | Tacrolimus | Ionomycin | GSK126 | Mitomycin C | Dimethyl sulfoxide

热门产品线：重组蛋白 | 化合物库 | 天然产物 | 染料试剂 | PROTAC | 同位素标记物 | 寡核苷酸

Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds | Oligonucleotides

品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
• 10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。