抗Ⅱ型胶原抗体

抗Ⅱ型胶原抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

抗Ⅱ型胶原抗体产品介绍

Ⅱ型胶原是软骨基质中的一种结构蛋白；Ⅱ型胶原不与Ⅰ、Ⅲ、Ⅳ、Ⅴ、Ⅵ胶原以及其它血清蛋白或非胶原性细胞外相关蛋白起交叉反应。
抗II型胶原抗体-主要用于Ⅱ型胶原分布及变态反应方面的研究。

Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This may result in diminished reactivity of some antibodies with denatured collagen or formalin fixed, paraffin embedded tissues.
Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
mol wt:156kDa
Other Aliases:
collagen, type II, alpha 1; collagen alpha-1(II); type II collagen; alpha-1 type II collagen; alpha1 type II collagen; Col2a1; AOM; Cartilage collagen; Chondrocalcin; COL11A3; COL2A1; COL2A1 protein; Collagen alpha 1(II) chain precursor; Collagen II alpha 1 polypeptide; Collagen type II alpha 1 (primary osteoarthritis spondyloepiphyseal dysplasia congenital); MGC131516; SEDC

zk-2087zk TSHR (Thyroid stimulating hormone receptor)促甲状腺素受体抗原
zk-1534zk MAP1LC3A(microtubule-associated protein 1 light chain 3)自噬微管相关蛋白轻链3抗原
zk-1147zk TSLC1 (tumor suppressor in lung cancer-1)肺癌肿瘤阻抑基因1抗原
zk-0826zk TTF-1 (Thyroid Transcription Factor-1)甲状腺核转录因子-1抗原
zk-1322zk Tubulin- Gamma微管蛋白-γ抗原
zk-2441zk TWIST protein peptideTWIST蛋白抗原
zk-1088zk T Beta10 peptide胸腺素β10抗原
zk-1929zk UCN(Urocortin)mouse ret新型血管活性因子UCN抗原(小鼠、大鼠)
zk-1403zk USF-1(upstream stimulatory factor 1)上游刺激因子1抗原
zk-1549zk Ubiquitin泛素蛋白
zk-1505zk VASH1(Vasohibin 1)兔抗血管抑制蛋白1抗原
zk-0396zk VCAM-1/CD106(Vascular cell adhesion molecule 1 isoform b precusor; CD106 antigen)血管内皮细胞粘附分子抗原
zk-0920zk VCAM-1/CD106 (Vascuolar cell adhesion molecule 1)血管内皮细胞粘附分子抗原
zk-1461zk VDAC peptide电压依赖性阴离子通道抗原
zk-1313zk VEGF血管内皮生长因子(多肽抗原)
zk-1957zk VEGF-A(Vascuoar endothelial growth factor A)血管内皮生长因子A抗原
zk-1586zk VEGF-C(Vascuoar endothelial growth factor-C)血管内皮生长因子C型抗原
zk-0565zk VEGFR2血管内皮生长因子受体2
zk-2089zk sVEGFR2可溶性血管内皮生长因子受体2
zk-1083zk VEGFR-3/FLt-4血管内皮细胞生长因子受体-3（多肽）
抗Ⅱ型胶原抗体