- 询价
- Abcam
- ZK-0102800
- 中国/美国/德国
- 2025年11月20日
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- 详细信息
- 技术资料
- 克隆性：
单克隆
- 抗体英文名：
Anti-STAT2 (signal t
- 抗体名：
信号转导和转录激活因子2(STAT2)抗体
信号转导和转录激活因子2(STAT2)抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
信号转导和转录激活因子2(STAT2)抗体产品介绍
转录调节因子（Transcriptin Regulators）
STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。
STATs are Signal Transducers and Activators of Transcription. STATs were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6).
STATs are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors. STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5. Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases. Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including SCID and leukemia, and programming gene expression in biological events such as embryonic development, apoptosis, organogenesis, innate immunity, adaptive immunity and cell growth regulation. STAT1 knockout mice are defective in interferon-mediated functions. STAT4 and STAT6 knockout mice show defective responses to IL12 and IL4, respectively. Analyses of STAT5a and STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland. STAT1/STAT2 form a heterodimer which, in association with a DNA-binding adapter protein, p48/IFN regulatory factor 9 (IRF9), is part of the ISGF3 transcription factor complex.
Specific functions of the various members of the STAT family are poorly understood. STAT1 and STAT2 form heterodimers that function as more potent inducers of transcription than the STAT1 homodimer. The unique acidic domain of the carbozk-terminal region of STAT2 may interact with cAMP-response-element binding protein. STAT2 has been shown to be activated by IFNalpha/beta and associate with the transcription factors p48, and P300.
mol wt:93kDa(human, rat); 101kDa(mo)
Other Aliases:
signal transducers and activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF3; MGC59816; P113; signal transducer and activator of transcription 2 113kD; STAT113
STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。
STATs are Signal Transducers and Activators of Transcription. STATs were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6).
STATs are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors. STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5. Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases. Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including SCID and leukemia, and programming gene expression in biological events such as embryonic development, apoptosis, organogenesis, innate immunity, adaptive immunity and cell growth regulation. STAT1 knockout mice are defective in interferon-mediated functions. STAT4 and STAT6 knockout mice show defective responses to IL12 and IL4, respectively. Analyses of STAT5a and STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland. STAT1/STAT2 form a heterodimer which, in association with a DNA-binding adapter protein, p48/IFN regulatory factor 9 (IRF9), is part of the ISGF3 transcription factor complex.
Specific functions of the various members of the STAT family are poorly understood. STAT1 and STAT2 form heterodimers that function as more potent inducers of transcription than the STAT1 homodimer. The unique acidic domain of the carbozk-terminal region of STAT2 may interact with cAMP-response-element binding protein. STAT2 has been shown to be activated by IFNalpha/beta and associate with the transcription factors p48, and P300.
mol wt:93kDa(human, rat); 101kDa(mo)
Other Aliases:
signal transducers and activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF3; MGC59816; P113; signal transducer and activator of transcription 2 113kD; STAT113
zk-5280R phospho-CTNNA1 (Ser641)磷酸化α-连环蛋白抗体
zk-5281R Cyclin E2周期素E2抗体
zk-5282R phospho-CaMK2 beta gamma delta (Thr287)磷酸化钙/钙调素依赖蛋白激酶CAMK2B/D/G抗体
zk-4097R CASC3肿瘤易感候选基因3抗体
zk-5283R phospho-CASC3(Tyr181)磷酸化肿瘤易感候选基因3抗体
zk-5269R phospho-CREB-1(Ser142)磷酸化CREB-1抗体
zk-5270R phospho-CREB-1(Ser121)磷酸化CREB-1抗体
zk-5287R phospho-CDK6 (Tyr24)磷酸化周期素依赖性激酶6抗体
zk-5147R CBL2原癌基因CBL2抗体
zk-4071R phospho-CBL2 (Tyr674)磷酸化原癌基因CBL2抗体
zk-4095R CTNNBIP1β链接素相互作用蛋白1抗体
zk-5266R phospho-CTNNBIP1 (Thr43+Ser50)磷酸化β链接素相互作用蛋白1抗体
zk-4074R phospho-Beta catenin (Tyr86) 磷酸化β 连环素蛋白抗体
zk-4520R Chloroplast protease叶绿体蛋白酶抗体（植物）
zk-5267R phospho-CDC27 (Ser427)磷酸化后期促进复合蛋白3抗体
zk-5258R Phospho-Cofilin (Tyr140)磷酸化丝切蛋白抗体
zk-5259R phospho-CFL1 (Tyr89)磷酸化丝切蛋白抗体
zk-5260R Phospho-CHK2 (ser33)磷酸化细胞周期检测点激酶2抗体
zk-5261R Phospho-cdc25A (Ser178)磷酸化细胞分裂周期蛋白25抗体
zk-5262R Phospho-cdc25A (Ser293)磷酸化细胞分裂周期蛋白25抗体
zk-4096R CDC27后期促进复合蛋白3抗体
zk-5264R phospho-CRK (Ser41)磷酸化CRK抗体
zk-5823R K Cadherin钙粘蛋白6抗体
zk-5824R Cadherin like 23钙粘蛋白23抗体
zk-6296R CDR2小脑变性相关蛋白2抗体
zk-6268R CRK7细胞分裂周期2相关蛋白激酶7抗体
zk-2273R CPa(Clostridium perfringens alpha toxin)A型产气荚膜梭菌(魏氏梭菌)
zk-5404R phospho-CK18(Ser34)磷酸化细胞角蛋白18抗体
zk-2950R Cytosine deaminase胞嘧啶脱氨酶抗体
信号转导和转录激活因子2(STAT2)抗体
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信号转导和转录激活因子2(STAT2)抗体
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