抑癌基因p14抗体

抑癌基因p14抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

抑癌基因p14抗体产品介绍

p14ARF是近年来发现的一种重要的抑癌基因,与细胞周期和凋亡的调控密切相关,p14ARF基因是细胞周期调控基因,它主要阻滞细胞于G1期和G2/M期，因此p14ARF与癌细胞的增殖和凋亡密切相关，在肿瘤的发生和演化中起着重要的作用。
p14ARF主要定位于细胞核,但也有部分定位于胞浆，与细胞周期有关。
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. CDKN2A. Gene Symbol: p14ARF; TP16; p16; CDKN2; MTS1; INK4a; CMM2; MLM; ARF; p16INK4a; INK4; p16-INK4a; p14; p16-INK4; p16INK4A; p16INK4; p19; p19ARF; CDK4I; MTS-1zk-13398R GSTA1谷胱甘肽S转移酶α1抗体
zk-13399R GSTK1谷胱甘肽S转移酶κ抗体
zk-3983R Galactose kinase半乳糖激酶1抗体
zk-3991R GYG2糖原蛋白2抗体
zk-3984R GALT磷酸半乳糖尿苷酸转移酶1抗体
zk-3990R GYG1糖原蛋白1抗体
zk-3989R Glycogen synthase 2葡萄糖合成酶2抗体
zk-3985R GOT2谷草转氨酶2抗体
zk-3987R Glucose 6 Phosphate Dehydrogenase葡萄糖-6磷酸脱氢酶抗体
zk-3988R GLUT5葡萄糖转运蛋白5抗体
zk-2359R Glycogen葡萄糖合成酶1抗体
zk-13502R GPATCH8G蛋白修补结构域蛋白8抗体
zk-13368R GK3甘油激酶3抗体
zk-13489R GOLPH3L高尔基体磷蛋白3样蛋白抗体
zk-8446R phospho-GluR1 (Ser849)磷酸化谷氨酸受体1抗体
zk-13498R GPATCH1/ECGPG蛋白修补结构域蛋白1抗体
zk-5374R phospho-GIT1(Tyr510) 磷酸化G蛋白偶联受体激酶相互作用蛋白1抗体
zk-5373R phospho-GIT1(Tyr554) 磷酸化G蛋白偶联受体激酶相互作用蛋白1
zk-2356R GKRP葡萄糖激酶调节蛋白抗体
zk-3893R GTPBP10GTP结合蛋白10抗体
zk-5376R phospho-G3BP1(Ser232)磷酸化Ras GTP酶活化蛋白结合蛋白1抗体
zk-4111R G3BP1Ras GTP酶活化蛋白结合蛋白1抗体
zk-4112R GABA A Receptor gamma 2γ氨基丁酸γ2受体/GABAA Rγ2抗体
zk-5367R phospho-GSK-3 Beta(Ser21+Ser29)磷酸化糖原合酶激酶3β抗体
zk-5372R phospho-GIT1(Ser375)磷酸化G蛋白偶联受体激酶相互作用蛋白1抗体
zk-5369R phospho-GATA1(ser142)磷酸化珠蛋白转录因子1抗体
zk-5370R phospho-GATA1(ser310)磷酸化珠蛋白转录因子1抗体
zk-4110R GIT1G蛋白偶联受体激酶相互作用蛋白1抗体
zk-5375R phospho-GATA6(Tyr271)磷酸化GATA结合蛋白6抗体
zk-5377R phospho-GABRG2(Ser327)磷酸化γ氨基丁酸γ2受体/GABAA Rγ2抗体
zk-3945R Glucagon Receptor胰高血糖素受体抗体
zk-5099R GDF3生长分化因子3抗体
抑癌基因p14抗体