- 询价
- R&D
- ZK-0102406
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Multidrug Resistance Protein (QCRL-3) Monoclonal Antibody (SIGNET)详细信息：
-
Description Monoclonal Antibody against MRP (Multi-Drug Resistance Associated Protein) (clone QCRL-3)
(Formerly Signet Catalog No: 8767-01)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone QCRL-3 Form Purified Antibody (in PBS + 0.1% NaN3 + 0.7% BSA) Host Mouse IsoType Multidrug Resistance Protein (QCRL-3) Monoclonal Antibody (SIGNET)IgG2a Specificity QCRL-3 reacts with a conformation-dependent epitope of MRP, a 190kDa transmembrane phosphoglycoprotein that is over expressed in various human multidrug resistant tumor cell lines. QCRL-3 was raised against membranes prepared from the human small cell lung cancer cell line, H69AR, which highly over expresses MRP. QCRL-3 does not cross-react with human MDR1 or MDR3. Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC) and immunocytochemistry (ICC), immunoprecipitation (IP) and flow cytometry. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - IHC: ≥1:40 for biotin based detection systems such as Signet’s USA Ultrastreptavidin Detection (SIG-32250).
Tissue Sections: Formalin-fixed, paraffin-embedded tissues
Pretreatment: For optimal staining, the sections should be pretreated with an antigen unmasking solution such as Sodium Citrate Buffer (SIG-31932).
Incubation: 60 minutes at room temperature.
Storage Multidrug Resistance Protein (QCRL-3) Monoclonal Antibody (SIGNET) References Almquist KC, Loe DW, Hipfner DR, Mackie JE, Cole SP, Deeley RG. Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell. Cancer Res. 55:102-110, 1995.
Hipfner DR, Gauldie SD, Deeley RG, Cole SP. Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res. 54(22):5788-92, 1994.
Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258(5088):1650-4, 1992.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - IHC: ≥1:40 for biotin based detection systems such as Signet’s USA Ultrastreptavidin Detection (SIG-32250).
- Multidrug Resistance Protein (QCRL-3) Monoclonal Antibody (SIGNET)
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Multidrug Resistance Protein (QCRL-3) Monoclonal Antibody (SIGNET)
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