- 询价
- R&D
- ZK-0102217
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Alpha-I Spectrin Monoclonal Antibody (SIGNET)保存于运输说明：
- Store at -20°C or below
- 详细信息：
-
Description Monoclonal Antibody against Human Alpha-I Spectrin
(Formerly Signet Catalog Nos: 9700-02, 9700-05, 9700-10)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 17C7 Form Tissue Culture Supernatant (in PBS + 0.1% NaN3) Host Mouse Species Reactivity Alpha-I Spectrin Monoclonal Antibody (SIGNET)Human IsoType IgG1 [Ab] 1 mg/mL Specificity Signet’s anti-human spectrin (Clone 17C7) is developed against the alpha I spectrin SH3 domain (Xu et al., 2000). Clone 17C7 is a specific marker for human, rat and mouse alpha I spectrin. It reacts with erythroid spectrin in red blood cells and in cerebellum. It does not crossreact with alpha II (nonerythroid) spectrin SH3 domain or recombinant human fodrin SH3 domain. In cerebellar cell cultures, clone 17C7 labels cell bodies consistent with localization of erythroid spectrin. In NIH 3T3 cells, clone 17C7 reacts with a 200 kDa protein which is a candidate marker of endocytic vesicles called macropinosomes (Xu et al., 2000 & 2001, Lamaze & Schmid, 1995).
This antibody was developed against a recombinant alpha I spectrin (erythroid spectrin) SH3 domain. It was subsequently purified via ammonium sulfate precipitation.Uses Alpha-I Spectrin Monoclonal Antibody (SIGNET)This antibody is effective in immunoblotting, immunofluorescence (IF), immunohistochemistry (IHC) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:1,000- 1:10,000
- IF: 1:100-1:500
- IHC: 1:10-1:50 (Frozen only)
- ELISA: 1:100,000-1:1,000,000
Storage Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Xu J, et al. Monoclonal antibodies to alphaI spectrin Src homology domain 3 associate with macropinocytic vesicles in nonerythroid cells. Brain Res 898:171-177, 2001. (WB, IF)
Xu J, et al. Human spectrin SH3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells. J Cell Science 113:3805-3814, 2000.
De Matteis, MA, Morrow JS. Spectrin tethers and mesh in the biosynthetic pathway.J. Cell Science 113:2331-2343, 2000.
Swanson JA, Watts C. Macropinosytosis. Trends Cell Biol 5:424-427, 1995.
Lamaze C, Schimid SL. The emergence of clathrin-independent pinocytic pathways.Curr Opin Cell Biol 7:573-580, 1995.
Bennett V, Gilligan DM. The spectrin-based membrane skeleton and micron scale organization of the plasma membrane. Annu Rev Cell Biol 9:27-66, 1993.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Alpha-I Spectrin Monoclonal Antibody (SIGNET)
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Alpha-I Spectrin Monoclonal Antibody (SIGNET)
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