- 询价
- R&D
- ZK-0100777
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Alpha-II Spectrin Monoclonal Antibody (SIGNET)详细信息：
-
Description Monoclonal Antibody against Human Alpha-II Spectrin
(Formerly Signet Catalog Nos: 9702-02, 9702-05, 9702-10)Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone D8B7 Form Tissue Culture Supernatant (in PBS + 0.1% NaN3) Host Mouse Species Reactivity Alpha-II Spectrin Monoclonal Antibody (SIGNET)Human IsoType igG2b Specificity Signet’s anti-human spectrin (Clone D8B7) is developed against the alpha II spectrin SH3 domain (Xu et al., 2001). Clone D8B7 is a specific marker for human, rat and mouse alpha II spectrin or fodrin. In cerebellar cell cultures, it labels axons and periphery of cell bodies consistent with localization of fodrin (reviewed in Bennett, 1993; Goodman, 1995 & De Matteis, 2000). It does not cross-react with alpha I (erythroid) spectrin SH3 domain.
This antibody was developed against a recombinant alpha II spectrin (non-erythroid spectrin or fodrin) SH3 domain. It was subsequently purified via ammonium sulfate precipitation.Uses This antibody is effective in immunoblotting, immunofluorescence (IF), immunohistochemistry (IHC) and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:100 - 1:1,000
- IF: 1:100 - 1:500
- IHC: 1:10 - 1:50 (Frozen only)
- ELISA: 1:100,000- 1:1,000,000
Storage Alpha-II Spectrin Monoclonal Antibody (SIGNET)Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Xu J, et al. Monoclonal antibodies to alphaI spectrin Src homology domain 3 associate with macropinocytic vesicles in nonerythroid cells. Brain Res 898:171-177, 2001. (WB, IF)
Xu J, et al. Human spectrin SH3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells. J Cell Science 113:3805-3814, 2000.
De Matteis, MA, Morrow JS. Spectrin tethers and mesh in the biosynthetic pathway.J. Cell Science 113:2331-2343, 2000.
Swanson JA, Watts C. Macropinosytosis. Trends Cell Biol 5:424-427, 1995.
Goodman SR, et al. Brain spectrin: of mice and men. Brain Res Bull 36:593-606, 1995.
Lamaze C, Schimid SL. The emergence of clathrin-independent pinocytic pathways.Curr Opin Cell Biol 7:573-580, 1995.
Bennett V, Gilligan DM. The spectrin-based membrane skeleton and micron scale organization of the plasma membrane. Annu Rev Cell Biol 9:27-66, 1993.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Alpha-II Spectrin Monoclonal Antibody (SIGNET)
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Alpha-II Spectrin Monoclonal Antibody (SIGNET)
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