- 询价
- R&D
- ZK-0101724
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Neurofilament 160/200 kD (NF-M+H) Monoclonal Antibody保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description Monoclonal antibody against neurofilament medium and high Clone RMdO-20 Form Ascites Host Mouse Species Reactivity Human, Mouse, Rabbit, Rat, Bovine, Hamster, Squid IsoType Neurofilament 160/200 kD (NF-M+H) Monoclonal AntibodyIgG1 [Ab] 3-5 mg/mL Specificity Neurofilaments are type IV intermediate filaments found in neurons. They consist of three protein subunits termed NF-H (200 kd), NF-M (160 kd) and NF-L (68 kd), each composed of 3 domains: an N-terminal head domain, an alpha-helix rich central rod domain and a C-terminal tail domain. Neurofilaments are obligate heteropolymers in vivo with assembly depending on a core NF-L subunit interacting with NF-M and NF-H subunits. Neurofilament phosphorylation plays a key role in the establishment of neurofilament density and axonal caliber. Phosphorylation of neurofilaments is also associated with the dynamic remodeling of cytoskeleton architecture during axonal growth, guidance and synaptogenesis.
The RMdO-20 antibody reacts with the medium and heavy neurofilaments of 160 kd and 200 kd respectively. It recognizes a non-phosphorylated epitope in the tail domain of NF-M+H and was raised against dephosphorylated adult rat neurofilament medium subunit.Uses This antibody is effective in immunoblotting, immunoprecipitation, immunohistochemistry and ELISA. Suggested Working Dilution Neurofilament 160/200 kD (NF-M+H) Monoclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval.
Western blot 1:1,000*Notes *MW = 200 and 160 kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. References VM Lee, MJ Carden, WW Schlaepfer, JQ Trojanowski. Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J. Neurosci. 7(11):3474-88, 1987.
VM Lee, L Otvos Jr, ML Schmidt, JQ Trojanowski. Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins. Proc. Natl. Acad. Sci. USA 85(19):7384-7388, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Neurofilament 160/200 kD (NF-M+H) Monoclonal Antibody
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Neurofilament 160/200 kD (NF-M+H) Monoclonal Antibody
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