- 询价
- R&D
- ZK-0101535
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- GAPDH Monoclonal Antibody详细信息：
-
Description Monoclonal Antibody against Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH, G3PDH and GPDH) Clone 1D4 Form Tissue Culture Supernatant (contains 10mM Sodium Azide) Host Mouse Species Reactivity Mammalian including Human, Cow, Pig, Mouse, Rat and Avian IsoType GAPDH Monoclonal AntibodyIgG1, k light chain [Ab] ~1 mg/mL Specificity Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. Because GAPDH as a protein expressed in large amounts and which is required at all times for an important "house keeping" functions, levels of GAPDH mRNA are often measured and used as standards in studies of mRNA expression. Increasingly, scientists are making use of specific antibodies to GAPDH in comparable studies of levels of protein expression. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue. Apart from a role in glycolysis, GAPDH may have other roles such as in the activation of transcription. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimers disease, and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntingtons disease. Associations with actin and tubulin have also been reported. The protein may also have a role in the regulation of apoptosis, and interestingly migrates from the cytoplasm into the nucleus when cells become apoptotic.
This antibody was raised against extensively purified pig GAPDH.Uses This antibody is effective in immunoblotting, immunofluorescence (IF) and immuocytochemistry (ICC). Suggested Working Dilution GAPDH Monoclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000 or lower*
- IF: 1:100
Notes * Predicted MW = 38kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. References Ellis RC, Earnhardt JN, Hayes RL, Wang KK, Anderson DK. Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats. J. Neurochem. 88:689-697, 2004.
Fortun J, Dunn WA, Joy S, Li J, Notterpek L. Emerging role for autophagy in the removal of aggresomes in schwann cells. J. Neurosci. 23:10672-10680, 2003.
Dastoor Z, Dreyer J-L. Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress. J. Cell Sci. 114:1643-1653, 2001.
Burke JR, Enghild JJ, Martin ME, Jou Y-S, Myers RM, Roses AD, Vance JM, Strittmatter WJ. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2:347-350, 1996.
Schulze H, Schuler A, Stuber D, Dobeli H, Langern H, Huber G. Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimers beta-amyloid precursor protein. J. Neurochem. 60:1915-22, 1993.
Morgenegg G, Winkler GC, Hubscher U, Heizmann CW, Mous J, Kuenzle CC. Glyceraldehyde-3-phosphate dehydrogenase is a nonhistone protein and a possible activator of transcription in neurons. J. Neurochem. 47:54-62, 1986.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - GAPDH Monoclonal Antibody
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GAPDH Monoclonal Antibody
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