- 询价
- R&D
- ZK-0101020
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
1 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Presenilin 1/C-Terminal (PS1/C-Term) Polyclonal Antibody, Purified保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description Polyclonal Antibody against Presenilin 1/C-Terminal (PS1/C-Term) Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Form Affinity Purified Antibody Host Rabbit Species Reactivity Presenilin 1/C-Terminal (PS1/C-Term) Polyclonal Antibody, PurifiedHuman [Ab] 0.4 mg/mL Specificity The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase complex catalyzes cleavage of a number of integral membrane proteins including Amyloid precursor protein, Notch, Erb4 and E-cadherin. The results of several recent studies indicate that the functional gamma secretase activity mostly arises from a low abundance very high molecular weight complex (>670 kDa). These data suggest that additional proteins may be present in these functional complexes or the functional complex is a higher order multimer of presenilin, aph-1, pen-2 and nicastrin.
PRB-355P was raised against a peptide sequence corresponding to the cytoplasmic loop (C-terminus) of PS1 and was subsequently antigen affinity purified.Uses Presenilin 1/C-Terminal (PS1/C-Term) Polyclonal Antibody, PurifiedThis antibody is effective in immunoblotting, immunocytochemistry (ICC) and immunoprecipitation (IP) Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:1,000
- ICC: 1:200
- IP: 1:200
Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Gu Y, Sanjo N, Chen F, Hasegawa H, Petit A, Ruan X, Li W, Shier C, Kawarai T, Schmitt-Ulms G, Westaway D, St George-Hyslop P, Fraser PE. The presenilin proteins are components of multiple membrane-bound complexes which have different biological activities. J Biol Chem 279(30):31329-31336, 2004.
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, George-Hyslop PS. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin1 and presenilin 2 complexes. J Biol Chem 275(35):27348-27353, 2000.
Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE. Carbozkl-terminal fragments of alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. J Biol Chem 275(47):36794-36802, 2000.
Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Presenilin 1/C-Terminal (PS1/C-Term) Polyclonal Antibody, Purified
- zk-0309R-Golzk Rabbit Anti-pig IgG/Gold胶体金标记的兔抗猪IgG
zk-0309R-zkE Rabbit Anti-pig IgG/PEPE标记的兔抗猪IgG
zk-0309R-zkE-zkY5 Rabbit Anti-pig IgG/PE-CY5PE-CY5标记的兔抗猪IgG
zk-0309R-zkE-zky7 Rabbit Anti-pig IgG/PE-Cy7PE-Cy7标记的兔抗猪IgG
zk-0309R-Bio Rabbit Anti-pig IgG/Bio生物素标记的兔抗猪IgG
zk-0293R-Bio Rabbit Anti-rat IgG/Bio生物素标记的兔抗大鼠IgG
zk-0369M-HRzk Mouse Anti-Rabbit IgM/HRP辣根过氧化物酶标记的小鼠抗兔IgM
zk-0295M-zkE-zky7 Mouse Anti-rabbit IgG/PE-Cy7PE-Cy7标记的小鼠抗兔IgG
zk-0295M-AF555 Mouse Anti-rabbit IgG/Alexa Fluor 555Alexa Fluor 555标记的小鼠抗兔IgG
zk-0295M-AF647 Mouse Anti-rabbit IgG/Alexa Fluor 647Alexa Fluor 647标记的小鼠抗兔IgG
zk-0295M-zky3 Mouse Anti-rabbit IgG/Cy3Cy3标记的小鼠抗兔IgG
zk-0295M-zkE-zkY5 Mouse Anti-rabbit IgG/PE-CY5PE-CY5标记的小鼠抗兔IgG
zk-0295M-zky5.5 Mouse Anti-rabbit IgG/Cy5.5Cy5.5标记的小鼠抗兔IgG
zk-0295M-AF350 Mouse Anti-rabbit IgG/Alexa Fluor 350Alexa Fluor 350标记的小鼠抗兔IgG
zk-0295M-AF488 Mouse Anti-rabbit IgG/Alexa Fluor 488Alexa Fluor 488标记的小鼠抗兔IgG
zk-0296R-AF350 Rabbit Anti-mouse IgG/Alexa Fluor 350Alexa Fluor 350标记的兔抗小鼠IgG
zk-0296R-AF647 Rabbit Anti-mouse IgG/Alexa Fluor 647Alexa Fluor 647标记的兔抗小鼠IgG
zk-0369M-AF488 Mouse Anti-Rabbit IgM/Alexa Fluor 488Alexa Fluor 488标记的小鼠抗兔IgM
zk-0335R-AF647 Rabbit Anti-Monkey IgG/Alexa Fluor 647Alexa Fluor 647标记的兔抗猴IgG
zk-0369M-zkE-zky3 Mouse Anti-Rabbit IgM/PE-Cy3PE-Cy3标记的小鼠抗兔IgM
zk-0369M-zkE-zkY5 Mouse Anti-Rabbit IgM/PE-CY5PE-CY5标记的小鼠抗兔IgM
zk-0293R-zky5 Rabbit Anti-rat IgG/Cy5Cy5标记的兔抗大鼠IgG
zk-0293R-zky5.5 Rabbit Anti-rat IgG/Cy5.5Cy5.5标记的兔抗大鼠IgG
zk-0293R-zkE Rabbit Anti-rat IgG/PEPE标记的兔抗大鼠IgG
zk-0293R-zkE-zky7 Rabbit Anti-rat IgG/PE-Cy7PE-Cy7标记的兔抗大鼠IgG
zk-0296R-FITzk Rabbit Anti-mouse IgG/FITCFITC标记的兔抗小鼠IgG
zk-0369M-RBITzk Mouse Anti-Rabbit IgM/RBITC罗丹明标记的小鼠抗兔IgM
zk-0296R-HRzk Rabbit Anti-mouse IgG/HRP辣根过氧化物酶标记的兔抗小鼠IgG
zk-0293M-HRzk Mouse Anti-rat IgG/HRP辣根过氧化物酶标记的小鼠抗大鼠IgG
zk-0369M-zkE-zky7 Mouse Anti-Rabbit IgM/PE-Cy7PE-Cy7标记的小鼠抗兔IgM
zk-0335R-HRzk Rabbit Anti-Monkey IgG/HRP辣根过氧化物酶标记的兔抗猴IgG
zk-0346R-Azk Rabbit Anti-rat IgM/AP碱性磷酸酶（AP）标记的兔抗大鼠IgM
zk-0369M-AF555 Mouse Anti-Rabbit IgM/Alexa Fluor 555Alexa Fluor 555标记的小鼠抗兔IgM
zk-0369M-AF647 Mouse Anti-Rabbit IgM/Alexa Fluor 647Alexa Fluor 647标记的小鼠抗兔IgM
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Presenilin 1/C-Terminal (PS1/C-Term) Polyclonal Antibody, Purified
询价
